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Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans

open access: yesmBio
Fungal sexual reproduction is controlled by the mating-type (MAT) locus. In contrast to a majority of species in the phylum Basidiomycota that have tetrapolar mating-type systems, the opportunistic human pathogen Cryptococcus neoformans employs a bipolar
Zhuyun Bian   +12 more
doaj   +6 more sources

Altered Stereostructures of the DNA-Binding Domains of Variant Mating Proteins of Ophiocordyceps sinensis and the Wild Insect–Fungal Complex [PDF]

open access: yesBiology
The MATα_HMGbox and HMG-box_ROX1-like domains of the MAT1-1-1 and MAT1-2-1 proteins, respectively, play essential roles in DNA binding and the subsequent regulation of gene transcription, controlling Ophiocordyceps sinensis sexual reproduction ...
Xiu-Zhang Li   +3 more
doaj   +3 more sources

Polyphasic characterization and mating type allele distribution of Monilinia laxa in Iranian stone fruit orchards [PDF]

open access: yesScientific Reports
Brown rot disease, caused by species of the genus Monilinia, is a significant fungal disease affecting pome and stone fruit trees. In this study, 565 samples were collected from symptomatic trees across six provinces of Iran between 2018 and 2022.
Hadi Golmohammadi   +3 more
doaj   +3 more sources

Structure of the Mating-Type Genes and Mating Systems of Verpa bohemica and Verpa conica (Ascomycota, Pezizomycotina)

open access: yesJournal of Fungi, 2023
Verpa spp. are potentially important economic fungi within Morchellaceae. However, fundamental research on their mating systems, the key aspects of their life cycle, remains scarce.
Wenhua Sun   +11 more
doaj   +2 more sources

The Cryptococcus neoformans STE11α gene is similar to other fungal mitogen‐activated protein kinase kinase kinase (MAPKKK) genes but is mating type specific [PDF]

open access: yesMolecular Microbiology, 2001
Partial sequence analysis of the Cryptococcus neoformans MATα mating type locus revealed the presence of a gene with substantial sequence similarity to other fungal mitogen‐activated protein (MAP) kinase kinase kinase (MAPKKK) genes. The C. neoformans gene, designated STE11α, showed the highest degree of similarity to the Neurospora crassa nrc‐1 ...
D L, Clarke   +4 more
openaire   +3 more sources

The Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type Genes.

open access: yesPLoS Pathogens, 2015
Morphological changes are critical for host colonisation in plant pathogenic fungi. These changes occur at specific stages of their pathogenic cycle in response to environmental signals and are mediated by transcription factors, which act as master ...
Alberto Elías-Villalobos   +4 more
doaj   +2 more sources

Mutations and Differential Transcription of Mating-Type and Pheromone Receptor Genes in Hirsutella sinensis and the Natural Cordyceps sinensis Insect-Fungi Complex

open access: yesBiology
Sexual reproduction in ascomycetes is controlled by the mating-type (MAT) locus. (Pseudo)homothallic reproduction has been hypothesized on the basis of genetic data from Hirsutella sinensis (Genotype #1 of Ophiocordyceps sinensis).
Xiu-Zhang Li   +4 more
doaj   +2 more sources

Shifting fungal reproductive mode by manipulation of mating type genes: obligatory heterothallism of Gibberella zeae [PDF]

open access: yesMolecular Microbiology, 2003
SummaryFungi capable of sexual reproduction use heterothallic (self‐sterile) or homothallic (self‐fertile) mating strategies. In most ascomycetes, a single mating type locus, MAT, with two alternative forms (MAT1‐1 and MAT1‐2) called idiomorphs, controls mating ability.
Jungkwan, Lee   +4 more
openaire   +3 more sources

Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction in Cryptococcus deneoformans. [PDF]

open access: yesPLoS Genetics
Sex-specific homeodomain (HD) proteins are key regulators of cell identity and sexual development in fungi, typically functioning as heterodimers to govern transcription. In the human fungal pathogens Cryptococcus neoformans and Cryptococcus deneoformans,
Jun Huang   +6 more
doaj   +2 more sources

A conserved C2H2 zinc finger protein, Rel1, links ribosome biogenesis to sexual development and antifungal susceptibility in a ubiquitous human fungal pathogen [PDF]

open access: yesApplied and Environmental Microbiology
Sexual development is a fundamental process that promotes environmental adaptation and the emergence of highly virulent and drug-resistant isolates in the human fungal pathogen Cryptococcus neoformans.
Lili Yan   +9 more
doaj   +2 more sources

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