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Essential genes encoded by the mating-type locus of the human fungal pathogen Cryptococcus neoformans

MBio
Fungal sexual reproduction is controlled by the mating-type (MAT) locus. In contrast to a majority of species in the phylum Basidiomycota that have tetrapolar mating-type systems, the opportunistic human pathogen Cryptococcus neoformans employs a bipolar
Ziyan Xu, Yeseul Choi
exaly   +6 more sources

Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction in Cryptococcus deneoformans. [PDF]

PLoS Genetics
Sex-specific homeodomain (HD) proteins are key regulators of cell identity and sexual development in fungi, typically functioning as heterodimers to govern transcription. In the human fungal pathogens Cryptococcus neoformans and Cryptococcus deneoformans,
Jun Huang, Anna E Lehmann, Patricia P Peterson, Ziyan Xu, Liping Xiong, Sheng Sun, Joseph Heitman   +6 more
doaj   +2 more sources

Dissecting the homeodomain MAT locus and engineering novel tripolar and bipolar mating systems in Cryptococcus amylolentus [PDF]

mBio
Sex in fungi is governed by the mating-type (MAT) locus, which exists as a bipolar, pseudobipolar, or tetrapolar system. The significance and impact of MAT on sexual reproduction, however, remain understudied.
Liping Xiong, Vikas Yadav, Sheng Sun, Joseph Heitman   +3 more
doaj   +2 more sources

Altered Stereostructures of the DNA-Binding Domains of Variant Mating Proteins of Ophiocordyceps sinensis and the Wild Insect–Fungal Complex [PDF]

Biology
The MATα_HMGbox and HMG-box_ROX1-like domains of the MAT1-1-1 and MAT1-2-1 proteins, respectively, play essential roles in DNA binding and the subsequent regulation of gene transcription, controlling Ophiocordyceps sinensis sexual reproduction ...
Xiu-Zhang Li, Yu-Ling Li, Wei Liu, Jia-Shi Zhu   +3 more
doaj   +2 more sources

Tracing the Origin of the Fungal α1 Domain Places Its Ancestor in the HMG-Box Superfamily: Implication for Fungal Mating-Type Evolution [PDF]

PLoS ONE, 2010
BackgroundFungal mating types in self-incompatible Pezizomycotina are specified by one of two alternate sequences occupying the same locus on corresponding chromosomes.
Shun-Wen Lu, Daniel R Ripoll, Christina Dixelius   +2 more
exaly   +2 more sources

Lineage-specific diversity of pheromone response pathway genes is independent of mating strategy in Ceratocystidaceae [PDF]

BMC Genomics
The pheromone-receptor system plays a crucial role in mate recognition and fertilisation of ascomycete fungi and is strongly regulated by proteins coded for in the mating-type locus.
Frances A. Lane, Brenda D. Wingfield, Michael J. Wingfield, P. Markus Wilken   +3 more
doaj   +2 more sources

A conserved C2H2 zinc finger protein, Rel1, links ribosome biogenesis to sexual development and antifungal susceptibility in a ubiquitous human fungal pathogen [PDF]

Applied and Environmental Microbiology
Sexual development is a fundamental process that promotes environmental adaptation and the emergence of highly virulent and drug-resistant isolates in the human fungal pathogen Cryptococcus neoformans.
Lili Yan, Man Chen, Yuanli Liu, Pengjie Hu, Yan Wang, Yanli Cao, Ye Huang, Xiuyun Tian, Xinping Xu, Fanglin Zheng   +9 more
doaj   +2 more sources

Chromosome-scale genome assembly of Naematelia sinensis (Jin Er mushroom) offers new insights into the distinct mating-type genomes feature and genome evolution [PDF]

Frontiers in Microbiology
Naematelia sinensis (Jin Er mushroom) is a gelatinous fungus of significant economic and medicinal value indigenous to China. As an obligate parasite that requires Stereum hirsutum for basidiomata formation, it serves as a distinctive model for ...
Zhenhui Shen, Xiangying Luo, Linlei Yang, Yao Cao, Yukang Zeng, Qingqing Lu, Lingshan Zi, Rongchun Li, Rongchun Li   +8 more
doaj   +2 more sources

Xenosiderophore transporter gene expression and clade-specific filamentation in Candida auris killifish (Aphanius dispar) infection [PDF]

Communications Biology
Candida auris is a critical priority fungal pathogen (World Health Organization). Clinical management is challenging, with high associated mortality, rapidly increasing antifungal resistance, and frequent nosocomial outbreaks.
Hugh Gifford, Tina Bedekovic, Nicolas Helmstetter, Jack Gregory, Qinxi Ma, Alexandra C. Brand, Duncan Wilson, Johanna Rhodes, Mark Ramsdale, Tetsuhiro Kudoh, Rhys A. Farrer   +10 more
doaj   +2 more sources

Differential Gene Expression between Fungal Mating Types Is Associated with Sequence Degeneration [PDF]

Genome Biology and Evolution, 2020
Abstract Degenerative mutations in non-recombining regions, such as in sex chromosomes, may lead to differential expression between alleles if mutations occur stochastically in one or the other allele. Reduced allelic expression due to degeneration has indeed been suggested to occur in various sex-chromosome systems.
Michael E Hood, Tatiana Giraud, Fantin Carpentier, Wen-Juan Ma   +3 more
openaire   +3 more sources