Results 111 to 120 of about 224,267 (330)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Sequences, annotation and single nucleotide polymorphism of the major histocompatibility complex in the domestic cat.

PLoS ONE, 2008
Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
Naoya Yuhki, James C Mullikin, Thomas Beck, Robert Stephens, Stephen J O'Brien   +4 more
doaj   +1 more source

Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle [PDF]

, 2009
gamma-herpesvirus Epstein-Barr virus (EBV) persists for life in infected individuals despite the presence of a strong immune response. During the lytic cycle of EBV many viral proteins are expressed, potentially allowing virally infected cells to be ...
A Rickinson, AD Hislop, AD Hislop, Alan B. Rickinson, Andrew D. Hislop, Andrew I. Bell, B Park, Bill Sugden, BJ Biegalke, BN Lilley, C Bogedain, Claire Shannon-Lowe, Daniëlle Horst, DJ Tenney, E Scotet, Elisabeth Kremmer, Emmanuel J. H. J. Wiertz, G Lautscham, HJ Delecluse, J Yuan, J Zuo, J Zuo, Jaap M. Middeldorp, JC Stinchcombe, JW Yewdell, JX Zhang, K Takada, L Young, LS Young, M Buisson, M Kishishita, M Rowe, Maaike E. Ressing, Martin Rowe, MC Gold, ME Ressing, MT Vossen, MW Munks, Nathan P. Croft, NM Steven, P Rivailler, PG Stevenson, R Feederle, S Keating, TA Groothuis, TR Jones, TR Jones, V Bohm, VA Pudney, WM van Grunsven, X Saulquin, Y Zeng   +51 more
core   +7 more sources

Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features

Advanced Healthcare Materials, EarlyView.
This study characterizes the presence of microplastics in human normal gastric, para‐tumor, and gastric tumor tissue and confirms the association between microplastic exposure and lymph node metastasis in gastric cancer. This study explores the transcriptomic changes induced by microplastic exposure, laying the foundation for further investigation into
Liqiao Chen, Jialin Li, Yan Wu, Han Bao, Xuesong Yang, Guoqing Lv, Ke Ji, Ji Zhang, Xiaojiang Wu, Kai Zhou, Jieli Xu, Jiatian Tang, Xiyuan Han, Anqiang Wang   +13 more
wiley   +1 more source

Influences of MHC Class II Haplotypes on Avian Influenza Traits in Thai Indigenous Chicken

The Journal of Poultry Science, 2006
Natural infections with influenza viruses have been reported in a variety of animal species including human, pigs, horses, sea mammals, mustelids and birds.
Kalaya Boonyanuwat, Sawat Thummabutra, Neramit Sookmanee, Voravit Vatchavalkhu, Voravit Siripholvat, Tadayoshi Mitsuhashi   +5 more
doaj   +1 more source

The Immune System [PDF]

, 1995
Modern biotherapy has been in use for some 30 years. The first types of biotherapy were nonspecific stimulators of the immune response, but advances in genetic engineering are allowing the mass production of pure biological products which are now being ...
Gallucci, Betty Bierut, McCarthy, Donna O.   +1 more
core   +1 more source

Characterization of antibody binding to swine leukocyte antigen class II [PDF]

, 2016
Indiana University-Purdue University Indianapolis (IUPUI)Though the elimination of carbohydrate xenoantigens has reduced the antibody barrier to clinical xenotransplantation, identification of additional targets of rejection could further increase the ...
Ladowski, Joseph Matthew
core   +1 more source

Tunable Enhancement of T Cell Expansion Through Modulation of Stiffness and Adhesion Receptor Engagement in an Engineered Hydrogel Platform

Advanced Materials, EarlyView.
We develop a hydrogel scaffold with controlled substrate stiffness and ligand functionalization for cell culture. Stiff substrates presenting CD3/CD28/CD2 ligands induce 2000‐fold expansion of T cells; this is 68% greater than the clinical standard (Dynabeads) and the first hydrogel capable of large‐scale expansion. Although expanding at a lower yield,
Niroshan Anandasivam, Rabia Ali, Lordean Gustinvil, Matthew J. Rosenwasser, Iain E. Dunlop, Derfogail Delcassian   +5 more
wiley   +1 more source

Consensus clustering and functional interpretation of gene-expression data [PDF]

, 2004
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Kellam, P., Liu, X., Martin, Nigel, Orengo, C.A., Swift, S., Tucker, A., Vinciotti, V.   +6 more
core   +2 more sources