Results 111 to 120 of about 7,394,141 (337)

KRAS, BRAF oncogene mutations and tissue specific promoter hypermethylation of tumor suppressor SFRP2, DAPK1, MGMT, HIC1 and p16 genes in colorectal cancer patients [PDF]

, 2016
BACKGROUND: Colorectal cancer is a serious disease that causes significant morbidity and mortality in developed countries. Genetic changes, such as mutations in proto-oncogenes and DNA repair genes, and loss of function in the tumor suppressor genes ...
Sari, Musa, Bagci, Gokhan, Turan, Mustafa, Karadayi, Kursat, Ozdemir, Ozturk, Bagci, Binnur   +5 more
core   +1 more source

Alterations of p16(INK4A) and p15(INK4B) genes in gastric carcinomas

, 1997
BACKGROUND. It has been suggested that cyclin-dependent kinase inhibitors (CDKIs), including p16 and p15, are tumor suppressor genes. Alterations of CDKIs have been found in most types of cancer.
Seo, Jin Y., Kim, Noe K., Jung, Chul W., Choe, Kuk J., Koeffler, H. Phillip, Kim, Byoung K., Lee, Young Y., Lee, Kuhn U., Kang, Shin H., Bang, Yung‐Jue   +9 more
core   +1 more source

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source

Expression of genes involved in the regulation of p16 in psoriatic involved skin

, 2006
It has been suggested that the up-regulation of the tumour suppressor p16 gene and induction of senescence protect the phenotype of psoriatic involved skin from malignant transformation.
Björntorp Mark, Elisabeth,, Asp, Julia,, Wennberg, Ann-Marie,, Jonsson, Marianne,, Lindahl, Anders,, Mölne, Lena,   +5 more
core   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Simultaneous Inactivation of the p16, p15, and p14 Genes Encoding Cyclin-Dependent Kinase Inhibitors in Canine T-lymphoid tumor cells [PDF]

The p16, p15, and p14 genes are widely known as tumor suppressor genes in human medicine. Although a large number of genetic and epigenetic aberrations in these genes have been reported in human malignancies, canine malignancies have not been well ...
244, 40709755, 藤原, 亜紀
core   +1 more source

Promoter hypermethylation of multiple genes in hydatidiform mole and choriocarcinoma

, 2004
The methylation status of genes in hydatidiform mole and choriocarcinoma and its significance is relatively unexplored. We investigated the methylation status of the promoter regions of six genes, p16, HIC-1, TIMP3, GSTP1, death-associated protein kinase
Hextan Y.S. Ngan, Tsao, SW, Xue, WC, Chan, KYK, Ngan, HYS, Chiu, PM, Kelvin Y.K. Chan, Hui-Chen Feng, Cheung, ANY, Sai-Wah Tsao, Annie N.Y. Cheung, Wei-Cheng Xue, Feng, HC, Pui-Man Chiu   +13 more
core   +1 more source

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Assessing the Diagnostic Accuracy of Salivary Biomarkers in Detecting Oral Squamous Cell Carcinoma

Journal of Pharmacy and Bioallied Sciences
Background: Attempts should be made to identify the molecule-based biomarkers, which give indication about the progression of precancer and malignancy of the oral area.
Priyanka Vinod Bansal, Liza Mohanty, Chinmay Raval, Inderjit M. Gowdar, Anshul Chopra, Bharti Gupta, Ramanpal S. Makkad   +6 more
doaj   +1 more source

p16 Overexpression and Human Papillomavirus Positivity in More Than 1000 Penile Cancers. [PDF]

Int J Cancer
ABSTRACT Penile cancer is a severe disease, and a large proportion is related to high‐risk (hr) human papillomavirus (HPV). P16 is used as an immunohistochemical marker of HPV in clinical diagnostics. Population‐based data on the prevalence of p16 in penile cancer is scarce.
Stærk MG, Toft BG, Stilling C, Elversang J, Kjær-Frifeldt S, Hjulskov SH, Stifter-Vretenar S, Schou MA, Aagaard M, Petersen PM, Jakobsen JK, Munk C, Kjær SK.   +12 more
europepmc   +2 more sources