Results 171 to 180 of about 2,017,768 (306)

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Transformation From Oxyntic Gland Neoplasm Into Advanced Gastric Cancer via <i>TP53</i> Mutation: A First Case Report. [PDF]

J Med Cases
Komatsu A, Rokutan H, Arai N, Nagasaka T, Kamino S, Fukagawa K, Ono S, Kanazawa N, Arai T.   +8 more
europepmc   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

P53 Competitively Binds P300 to Suppress HIF-1α/TFRC-Mediated Ferroptosis and Promote Doxorubicin Resistance in Breast Cancer. [PDF]

FASEB J
Yu X, Yao L, Zhang S, Huang X, Xu A, Fu D.   +5 more
europepmc   +1 more source

THE P53-NMNAT2 FEEDBACK REGULATORY LOOP: MECHANISMS UNDERLYING P53 ACTIVATION

, 2011
The tumor suppressor p53 acts as a master transcription factor that controls hundreds of effecter genes in response to various cellular stresses. The flexibility of p53 to regulate its target genes with distinct functions (growth arrest, DNA repair ...
Pan, Luzhe
core  

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

p53-mediated epigenetic regulation in the pathogenesis of endometriosis. [PDF]

Epigenetics
Wang J, Liao Q, Feng X.
europepmc   +1 more source

Study on the Transcription Regulation of Breast Cancer Amplified Sequence 2 (BCAS2) by p53 Tumor Suppressor

, 2010
新穎分子BCAS2已被發現在乳癌細胞株MCF7及MDA-MB-231，以及一些乳癌患者之臨床組織切片中，發現有基因放大或過度表現的的現象，並可能與乳癌細胞的侵襲性和遠端轉移有關。在本實驗室的研究中，發現默化BCAS2會導致MCF7細胞發生細胞凋亡，且細胞聚落形成能力降低。並發現BCAS2可以和抑癌蛋白p53結合，阻礙p53對下游目標基因如p21的轉錄活化，因此是一個p53的負向調控分子。53為細胞中最重要的抑癌分子之一，約有百分之五十以上的癌症被發現含有突變的p53 ...
林奕瑄, Lin, Yi-Hsuan
core  

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Single-Cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling. [PDF]

Cancer Med
Tahara S, Iguchi-Manaka A, Takeuchi N, Matsuo T, Shibuya A, Shibuya K, Ozaki H.   +6 more
europepmc   +1 more source