Results 191 to 200 of about 2,151,650 (259)

Opportunities in cancer gene therapy: inhibiting MDM2 and restoring p14ARF as a means to activate p53. [PDF]

Mol Cell Biochem
de Oliveira SB, Alves ALV, Niitsuma BN, Antunes F, Marinho GB, Amanatidis GL, Luz J, Barbosa M, Zambotti PEO, Rodrigues OA, Strauss BE.   +10 more
europepmc   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

EXPRESSION OF CONCERN: Ser⁴⁶ Phosphorylation of p53 Is Not Always Sufficient to Induce Apoptosis: Multiple Mechanisms of Regulation of p53-Dependent Apoptosis. [PDF]

Genes Cells
europepmc   +1 more source

Evaluation of novel targeted small-molecule therapeutics in desmoplastic small round cell tumor (DSRCT) cells. [PDF]

J Cancer Res Clin Oncol
Hahn A, Hentschel J, Saleem S, Becker S, Liehr T, Schober A, Krämer OH, Sonnemann J, Marx C.   +8 more
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

The Circadian Clock in Glioblastoma: Mechanisms and Therapeutic Potential. [PDF]

Clocks Sleep
Ghorbani Shirkouhi S, Kamari F, Høilund-Carlsen PF, Blaabjerg M, Alavi A, Poulsen FR, Revheim MR, Pereira da Silva AM, Andalib S.   +8 more
europepmc   +1 more source

CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells

Advanced Science, EarlyView.
AARS2 functions as an intracellular lactate sensor and lactyltransferase, catalyzing CD112 K412 lactylation to block ubiquitination‐dependent degradation and stabilize CD112. This pathway suppresses CD8+ T‐cell and NK‐cell cytotoxicity, enabling dual immune evasion.
Zhuoshuo Xu, Xinyu Zhang, Fang Dong, Nenghao Shen, Jun Zhou, Zihan Xi, Zhenghao Wu   +6 more
wiley   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

circMARK3 serves as a sponge of miR-205a to promote senescence of follicular granulosa cells in laying hens via regulating LIN9. [PDF]

Poult Sci
Liao CM, Wei YM, Xiang JL, Wang YX, Zhao XY, Zhang Y, Chen YQ, Yin HD.   +7 more
europepmc   +1 more source