Results 71 to 80 of about 2,017,768 (306)

The Origins and Evolution of the p53 Family of Genes [PDF]

Cold Spring Harbor Perspectives in Biology, 2009
A common ancestor to the three p53 family members of human genes p53, p63, and p73 is first detected in the evolution of modern-day sea anemones, in which both structurally and functionally it acts to protect the germ line from genomic instabilities in response to stresses.
Vladimir A, Belyi, Prashanth, Ak, Elke, Markert, Haijian, Wang, Wenwei, Hu, Anna, Puzio-Kuter, Arnold J, Levine   +6 more
openaire   +2 more sources

A Chromatin-Focused siRNA Screen for Regulators of p53-Dependent Transcription

G3: Genes, Genomes, Genetics, 2016
The protein product of the Homo sapiens TP53 gene is a transcription factor (p53) that regulates the expression of genes critical for the response to DNA damage and tumor suppression, including genes involved in cell cycle arrest, apoptosis, DNA repair ...
Morgan A. Sammons, Jiajun Zhu, Shelley L. Berger   +2 more
doaj   +1 more source

Prognostic significance and gene expression profiles of p53 mutations in microsatellite-stable stage III colorectal adenocarcinomas. [PDF]

PLoS ONE, 2012
Although the prognostic value of p53 abnormalities in Stage III microsatellite stable (MSS) colorectal cancers (CRCs) is known, the gene expression profiles specific to the p53 status in the MSS background are not known.
Venkat R Katkoori, Chandrakumar Shanmugam, Xu Jia, Swaroop P Vitta, Meenakshi Sthanam, Tom Callens, Ludwine Messiaen, Dongquan Chen, Bin Zhang, Harvey L Bumpers, Temesgen Samuel, Upender Manne   +11 more
doaj   +1 more source

Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms. [PDF]

, 2008
PPP1R13L was initially identified as a protein that binds to the NF-[kappa]B subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action.
Magdalena J. Laska, Anka Bric, Uffe Birk Jensen, Bjørn A. Nexø, Ulla Vogel, Scott Lowe, Stephen Hearn, Lars Zender   +7 more
core  

Deciphering c-MYC-regulated genes in two distinct tissues [PDF]

, 2011
Background: The transcription factor MYC is a critical regulator of diverse cellular processes, including both replication and apoptosis. Differences in MYC-regulated gene expression responsible for such opposing outcomes in vivo remain obscure.
Lesley Ward, Heather Turner, Michael Khan, Ward, Lesley (Lesley A.), Brown, Helen, Turner, Heather, Helen Brown, Hunter, Ewan, Ward, Lesley, Khan, Michael, Samuel C Robson, Stella Pelengaris, Brown, Helen (Helen E.), Robson, Samuel C, Robson, Samuel Charles, Pelengaris, Stella, Ewan Hunter, Turner Heather, Hunter Ewan, Pelengaris Stella, Ward Lesley, Khan Michael, Brown Helen, Robson Samuel C   +23 more
core   +5 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53 [PDF]

, 2010
Background The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-
Ahmed, Shafiq U., Milner, J, Jack Ford, Li, Han, Li, H, Ford, J, Serrano, M, Lynch, CJ, Milner, Jo, Ford Jack, Han Li, Blagosklonny, Mikhail V., Ahmed, Shafiq, Allison, SJ, Jo Milner, Simon J Allison, Simon J. Allison, Manuel Serrano, Warnock Lorna J., Warnock, LJ, Lorna J Warnock, Zahid H. Shah, Shafiq U Ahmed, Lorna J. Warnock, Serrano, Manuel, Shah, ZH, Lynch Cian J., Shah, Zahid H., Allison, Simon J., Shah Zahid H., Shafiq U. Ahmed, Serrano Manuel, Milner Jo, Cian J. Lynch, Lynch, Cian J., Li Han, Ahmed Shafiq U., Allison Simon J., Ford, Jack, Warnock, Lorna J., Cian J Lynch, Zahid H Shah   +41 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Transcriptional Activation of the MUC2 Gene by p53 [PDF]

Journal of Biological Chemistry, 2002
MUC2 is one of the major components of mucins that provide a protective barrier between epithelial surfaces and the gut lumen. We investigated possible alterations of MUC2 gene expression by p53 and p21(Sdi1/Waf1/Cip1) in a human colon cancer cell line, DLD-1, establishing subclones in which a tetracycline-regulatable promoter controls exogenous p53 ...
Keizou, Ookawa, Toshihiro, Kudo, Shu, Aizawa, Hiroshi, Saito, Shigeki, Tsuchida   +4 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source