Results 91 to 100 of about 2,151,650 (259)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Role of p53 in pseudorabies virus replication, pathogenicity, and host immune responses
Veterinary Research, 2019 As a key cellular transcription factor that plays a central role in cellular responses to a broad range of stress factors, p53 has generally been considered as a host cell restriction factor for various viral infections. However, the defined roles of p53
Xun Li +5 more
doaj +1 more source
A novel regulator of the p53-mediated mitochondrial apoptotic pathway [PDF]
, 2008 The p53 tumor suppressor protein induces apoptosis in response to genotoxic and environmental stress. Recent studies have revealed the existence of a transcription-independent mitochondrial p53 apoptosis pathway, however the mechanism regulating p53 ...
Bo Young Ahn +3 more
core
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Genes responsive to p53 activity.
, 2016 Genes responsive to p53 activity.
Douglas D. Richman (168764) +9 more
core +1 more source
Hypergravity Induces Phosphorylation of p53 at Serine 15, but not an Expression of p53-downstream Genes [PDF]
, 2004 We investigated the p53 signaling pathway induced by hypergravity in the human glioblastoma cell line A 172. Hypergravity (20×g) induced the accumulation of p53 and the phosphorylation of p53 at Ser-15.
Miwa IDE +7 more
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein
Cellular and Molecular Life SciencesThe p53 tumor suppressor exhibits antiviral activity. The viral replication is also inhibited by interferons (IFNs), cytokines that regulate immune genes via STAT transcription factors.
Agnieszka Będzińska +4 more
doaj +1 more source
PLoS ONE, 2013 The p53 tumor suppressor gene has a common polymorphism at codon 72 that alters its function. We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to ...
Gregory Azzam +3 more
doaj +1 more source