Results 111 to 120 of about 2,017,768 (306)

Modest effect of p53, EGFR and HER-2/neu on prognosis in epithelial ovarian cancer: a meta-analysis [PDF]

, 2009
Background: P53, egfr and her-2/neu are the most frequently studied molecular biological parameters in epithelial ovarian cancer, but their prognostic impact is still unequivocal.
de Jong, S., de Vries, E.G.E., de Bock, G.H.; id_orcid, Boezen, M., Post, W.J., van der Zee, A.G.J., de Vries, E.G.E.; id_orcid, Crijns, A.P.G., de Jong, S.; id_orcid, de Graeff, P., de Bock, G.H.   +10 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

The Sonification of the p53 Gene

Haliç Üniversitesi Sağlık Bilimleri Dergisi
The mapping of the sequences of our genes by the Human Genome Project, which is perhaps one of the greatest discoveries in human history, has been groundbreaking in the world of science, also motivated the intensification of interdisciplinary studies. In recent years, translating DNA into musical notes has become an interesting topic for scientists and
Vildan Volkan, Ecrin Yürükoğulları, Yusuf Eren Tüzün, Berçem Seven   +3 more
openaire   +1 more source

Role of p53 in pseudorabies virus replication, pathogenicity, and host immune responses

Veterinary Research, 2019
As a key cellular transcription factor that plays a central role in cellular responses to a broad range of stress factors, p53 has generally been considered as a host cell restriction factor for various viral infections. However, the defined roles of p53
Xun Li, Wei Zhang, Yunjia Liu, Jiaxun Xie, Chuanhuo Hu, Xiaoye Wang   +5 more
doaj   +1 more source

Strukturelle und funktionelle Untersuchung der p53-Familie, im Besonderen p63 [PDF]

, 2009
The transcription factor p63 is part of the p53 protein family, which consists of three members, p53, p63 and p73. P63 shares structural similarity with all family members, but is associated to different biological functions than p53 or p73. While p53 is
Weber, Tobias Alexander
core  

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance [PDF]

, 2011
The p53 tumour suppressor is a transcriptional activator that controls cell fate in response to various stresses. p53 can initiate cell cycle arrest, senescence and/or apoptosis via transactivation of p53 target genes, thus preventing cancer onset ...
Rudi Lurz, Kathryne Brownless, Michael B. Sherman, Andrei L. Okorokov, Brownless, K., Lurz, R., Okorokov, A.L., Ricardo Aramayo, Sherman, M.B., Orlova, Elena, Aramayo, Ricardo, Elena V. Orlova   +11 more
core   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein

Cellular and Molecular Life Sciences
The p53 tumor suppressor exhibits antiviral activity. The viral replication is also inhibited by interferons (IFNs), cytokines that regulate immune genes via STAT transcription factors.
Agnieszka Będzińska, Barbara Łasut-Szyszka, Małgorzata Krześniak, Agnieszka Gdowicz-Kłosok, Marek Rusin   +4 more
doaj   +1 more source

CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest.

PLoS ONE, 2013
The p53 tumor suppressor gene has a common polymorphism at codon 72 that alters its function. We previously reported that the proline 72 polymorphic variant of p53 (P72) demonstrates increased ability to transactivate a subset of genes, relative to ...
Gregory Azzam, Xuting Wang, Douglas Bell, Maureen E Murphy   +3 more
doaj   +1 more source