Comparative genomic insights into the genus Pantoea: genetic determinants of ecological lifestyle diversity and plant growth-promoting potential. [PDF]
World J Microbiol BiotechnolRimes-Casais FF +2 more
europepmc +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Morphology and Comparative Transcriptome Analysis of Resistant and Susceptible Bitter Gourd (<i>Momordica charantia</i> L.) Reveals the Molecular Response Related to Powdery Mildew Resistance. [PDF]
J Fungi (Basel)Xia L +7 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Locked tight (mostly): Histone ubiquitylation by PRC1 isn't always required for H3K27me3-dependent gene silencing. [PDF]
Plant CellOsborne R.
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Complete Mitochondrial Genomic Characteristics and Phylogenetic Analysis of the Medicinal Plant <i>Peperomia leptostachya</i>. [PDF]
Genes (Basel)Ying M, Shi J, Shen Z, Ye Q.
europepmc +1 more source