Unexpected enrichment of antibiotic resistance genes in recirculating aquaculture effluents of rainbow trout (<i>Oncorhynchus mykiss</i>): microbial community assembly and mobile genetic elements as key drivers. [PDF]
Front MicrobiolYang X, Li L, Zhang J, Qu J, Xu S.
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Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
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Unveiling differential gene expression and pathways in clear cell renal cell carcinoma with sarcomatoid transformation. [PDF]
PeerJFoong YX +6 more
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Advanced Science, EarlyView.This study reveals that age‐related LMNB1 deficiency in mesenchymal stem cells epigenetically upregulates SLC7A11, triggering actin disulfidptosis and mitochondrial dysfunction. This cascade impairs bone formation in senile osteoporosis. Furthermore, researchers identified the FDA‐approved drug naldemedine as a targeted SLC7A11 inhibitor to reverse ...
Wenhui Yu +12 more
wiley +1 more source
Prime Editing-Based Functional Characterization Supports a Likely Pathogenic Interpretation of <i>NF1</i> c.6394T>C (p.Ser2132Pro). [PDF]
Genes (Basel)Wu J, Li G, Liu S, Ma C, Wang X.
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Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities
AGING MEDICINE, EarlyView.Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
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Changes in Ras and Ras-Associated GTPases During Maturation of Porcine Cumulus Cells and Oocytes. [PDF]
Animals (Basel)Nam Y, Song H, Seok E, Lee SH.
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Agribusiness, EarlyView.ABSTRACT Food systems have a significant impact on environmental sustainability, underscoring the need for innovative technologies to support more sustainable agricultural methods. However, the adoption of these technologies hinges on consumer acceptance, making the analysis of consumer perceptions essential.
Greta Castellini, Guendalina Graffigna
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Mechanistic and Clinical Perspectives on Traditional Chinese Medicine in Thyroid Cancer Management. [PDF]
Biomol Ther (Seoul)Bai Y +6 more
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Annals of Gastroenterological Surgery, EarlyView.KRAS mutation demonstrated a prognostic impact according to primary tumor sidedness, independent of tumor morphology, in patients undergoing hepatectomy for colorectal liver metastases. A nomogram integrating biological and clinicopathological factors was developed to provide continuous biological risk assessment.
Yuzo Umeda +9 more
wiley +1 more source