Results 161 to 170 of about 202,778 (267)

RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathway. [PDF]

iScience
Wilmerding A, Richard A, Macagno N, Hirsinger E, Gharsalli T, Bellenger L, Naouar N, Gaudy C, Mallet S, Degardin N, Bouteille L, Caruso N, Duprez D, Graba Y, Medjkane S, Etchevers HC, Delfini MC.   +16 more
europepmc   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

When cells rebel: a comparative genomics investigation into marsupial cancer susceptibility. [PDF]

Mol Biol Evol
Petrohilos C, Peel E, Silver LW, O'Neill RJ, Grady PGS, Hogg CJ, Belov K.   +6 more
europepmc   +1 more source

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H.G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce BJ van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Pan-RAS Inhibitors: Expanding Therapeutic Potential and Evading Resistance. [PDF]

Cancers (Basel)
Ramesh S, Wang J, Huang CH, Moore AM, Fadlalla K, Berry KL, Maxuitenko YY, Chen X, Keeton AB, El-Rayes B, Buchsbaum DJ, Budhwani KI, Zhou G, Mitra AK, Piazza GA.   +14 more
europepmc   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source

Multi‑omics factor analysis reveals a RAS mutant-like metabolically distinct AML subgroup resistant to venetoclax

Schuringa JJ, Sternadt D, Hogeling S, Oudejans L, Rose Nl, Huls G, Peraira-Martins D.   +6 more
europepmc   +1 more source

Pathogen-Specific Regulation of Renin-Angiotensin System Genes in Epithelial Cells: A Comparative Study of SARS-CoV-2 Spike Protein N-Terminal Domain Fragment and Bacterial Lipopolysaccharide. [PDF]

Pathogens
Yılmaz A, Turk S, Malkan UY, Haznedaroglu İC, Gocer S, Ozguven SV, Turk C.   +6 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

RAS signaling in lung adenocarcinoma is defined by lineage context and DUSP4 loss. [PDF]

JCI Insight
Kim M, Lamlertthon W, Jo H, Cui Y, Yeon M, Choi HY, Hoadley KA, Smeltzer MP, Hayward MC, Wilkerson MD, Makowski L, Hayes DN.   +11 more
europepmc   +1 more source