Results 211 to 220 of about 202,778 (267)

RAS Genes and Cancer

2014
The three RAS genes (HRAS, KRAS, and NRAS) comprise the most commonly mutated oncogene family in human cancer. RAS genes encode highly related small GTPases that are key regulators of cytoplasmic signaling networks that include the Raf-MEK-ERK mitogen-activated protein kinase cascade and the PI3K-Akt signaling cascade. There is increasing evidence that
Tikvah K. Hayes, Jeran K. Stratford, Andrea Wang-Gillam, Channing J. Der   +3 more
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Dictyostelium ras genes

1995
Abstract Five ras genes (rasB, rasC, rasD, rasG and rasS) and one rap gene (rap1) have been isolated and characterized in the cellular slime mold Dictyostelium discoideum (Daniel etal. 1993,1994; Reymond etal. 1984; Robbins eta/. 1989,1990).
Juliet Daniel, Gerald Weeks, George B Spiegelman   +2 more
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Incidence of ras gene mutations in neuroblastoma

European Journal of Pediatrics, 1988
Using a rapid dot-blot screening procedure based on DNA amplification and hybridization to synthetic oligonucleotide probes, we investigated 18 neuroblastomas in various clinical stages for the presence of ras mutations. In none of the samples was a mutation in the relevant codons 12, 13 or 61 of Ha-ras, Ki-ras or N-ras found.
K, Ballas, J, Lyons, J W, Janssen, C R, Bartram   +3 more
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A novel ras-related gene family

Cell, 1985
We have identified a new family of ras genes, the rho genes, which share several properties with the more classical ras gene family consisting of N-, K-, and H-ras. The rho genes, first isolated from a cDNA library from the abdominal ganglia of Aplysia, encode proteins that share 35% amino acid homology with H-ras. Evolutionarily conserved counterparts
P, Madaule, R, Axel
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Targeting Ras Genes in Kidney Disease

Nephron Experimental Nephrology, 2004
Certain changes in cellular function are characteristic of renal disease. Foremost among these is the excessive proliferation of cells, but other phenotypic changes include dysregulated apoptosis, migration, adhesion, contraction, secretion, and receptor expression. Recent advances in cell biology have revealed an extensive role for the small monomeric
Hendry, B M, Sharpe, C C
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H-RAS, K-RAS, and N-RAS Gene Activation in Human Bladder Cancers

Cancer Genetics and Cytogenetics, 2000
Bladder cancer is one of the leading causes of cancer death in most developed countries. In this work, 19 bladder cancer specimens, along with their infiltrations of the urinary bladder wall from the same patients, were examined for the presence of H-RAS, K-RAS, and N-RAS activation using a polymerase chain reaction-restriction fragment length ...
B, Przybojewska, A, Jagiello, P, Jalmuzna   +2 more
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What's new in ras genes? Physiological role of ras genes in signal transduction and significance of ras gene activation in tumorigenesis.

Pathology, research and practice, 1997
Ras gene mutations have been found with variable prevalence in different tumor types. While during the past decade a lot of information has been accumulated on the frequency of ras oncogene activation in tumors, the last two years brought considerable progress in elucidating molecular mechanisms of signal transduction for which cellular ras proteins ...
V, Waldmann, H M, Rabes
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The Function of Ras Genes in Saccharomyces Cerevisiae

1990
Publisher Summary This chapter describes the function of RAS genes in the yeast Saccharomyces cerevisiae and the components of the pathway in which it acts. Yeast RAS proteins share considerable homology with the mammalian RAS proteins. A short sequence including an invariant cysteine residue is always found at the carboxyl end of all RAS proteins ...
J R, Broach, R J, Deschenes
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The ras Gene Family

1986
The ras gene family in mammalian cells consists of five closely related members: the Harvey and Kirsten ras genes (c-Ha-ras1 and c-Ki-ras2), an inactive pseudogene of each (c-Ha-ras2 and c-Ki-ras1; see Hall 1984) and the N-ras gene. There are also several distinctly related genes designated rho (ras-homologous; Madaule and Axel 1985).
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Different Patterns of Gene Expression in ras-Resistant and ras-Sensitive Cells

JNCI Journal of the National Cancer Institute, 1991
We have shown previously that nontumorigenic NIH 3T3 cells can be made tumorigenic and metastatic by transfection and expression of activated ras, whereas in LTA cells, which are tumorigenic but nonmetastatic, the degree of malignancy is not altered by ras.
A B, Tuck, S M, Wilson, R, Khokha, A F, Chambers   +3 more
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