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The ras gene family and human carcinogenesis
Mutation Research/Reviews in Genetic Toxicology, 1988It has been well established that specific alterations in members of the ras gene family, H-ras, K-ras and N-ras, can convert them into active oncogenes. These alterations are either point mutations occurring in either codon 12, 13 or 61 or, alternatively, a 5- to 50-fold amplification of the wild-type gene. Activated ras oncogenes have been found in a
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Cancer surveys, 1987
Members of the ras multigene family have been found in virtually all eukaryotes, from yeast to mammals. ras is required for normal cell growth in the yeast Saccharomyces cerevisiae and in at least some mammalian cells. These genes induce tumorigenic transformation of established NIH 3T3 cells by increased expression of a normal ras gene, certain point ...
D R, Lowy, B M, Willumsen
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Members of the ras multigene family have been found in virtually all eukaryotes, from yeast to mammals. ras is required for normal cell growth in the yeast Saccharomyces cerevisiae and in at least some mammalian cells. These genes induce tumorigenic transformation of established NIH 3T3 cells by increased expression of a normal ras gene, certain point ...
D R, Lowy, B M, Willumsen
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Ras-genes and cellular transformation
European Journal of Cancer and Clinical Oncology, 1985Brown R +5 more
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Anticancer research, 1989
Human c-myc and normal or mutant T24 H-ras1 genes either linked to the regulatory sequences of the human metallothionein IIa gene or unlinked have been employed individually or in combination to transfect early passage Chinese hamster lung cells.
Spandidos, Demetrios A., Lang, J. C.
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Human c-myc and normal or mutant T24 H-ras1 genes either linked to the regulatory sequences of the human metallothionein IIa gene or unlinked have been employed individually or in combination to transfect early passage Chinese hamster lung cells.
Spandidos, Demetrios A., Lang, J. C.
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Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 1999
ras gene mutations have been described with varying frequency in several types of human malignancies. To determine the incidence and type of ras mutations in human soft tissue tumors, we studied 45 sarcomas, including 27 malignant fibrous histiocytomas (MFHs), 10 liposarcomas, 2 rhabdomyosarcomas, and 6 leiomyosarcomas.
J, Yoo, R A, Robinson, J Y, Lee
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ras gene mutations have been described with varying frequency in several types of human malignancies. To determine the incidence and type of ras mutations in human soft tissue tumors, we studied 45 sarcomas, including 27 malignant fibrous histiocytomas (MFHs), 10 liposarcomas, 2 rhabdomyosarcomas, and 6 leiomyosarcomas.
J, Yoo, R A, Robinson, J Y, Lee
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A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
Cell, 2016Yogesh K Gupta +2 more
exaly