Results 241 to 250 of about 211,660 (314)

Hh and EGFR-Ras signaling promote distinct steps of tumor progression in the Drosophila follicle epithelium. [PDF]

Nat Commun
Anschütz S, Müller H, Schubert A, Peralta JM, Nystul TG, Rust K.   +5 more
europepmc   +1 more source

Clinical utility and genetic landscape of exome sequencing in a large pediatric epilepsy cohort: Insights from a Turkish tertiary care center

Epileptic Disorders, EarlyView.
Abstract Objective To evaluate the diagnostic utility and genetic spectrum of next‐generation sequencing (NGS) in a large, well‐phenotyped cohort of Turkish pediatric patients with epilepsy of unknown etiology. Methods Between January 2021 and December 2024, 250 children (115 female, 135 male) with unexplained epilepsy underwent either whole‐exome ...
Derya Karaer, Beste Kipçak Yüzbaşı, İpek Şahin, Olcay Güngör, Kadri Karaer   +4 more
wiley   +1 more source

RAS/BRAF wild-type metastatic high-methylated colorectal cancer has gene expression patterns related to MSI-H and BRAF V600E mutant: a translational research. [PDF]

Sci Rep
Wakayama S, Takahashi S, Ouchi K, Sakamoto Y, Denda T, Takashima A, Komatsu Y, Nakamura M, Ohori H, Yamaguchi T, Kobayashi Y, Baba H, Kotake M, Amagai K, Kondo H, Shimada K, Yamada Y, Sato A, Yuki S, Okita A, Komine K, Watanabe M, Morita S, Ishioka C.   +23 more
europepmc   +1 more source

The small molecule simufilam dose‐dependently attenuates the worsening of seizures in a mouse model of tuberous sclerosis complex

Epilepsia, EarlyView.
Abstract Objective Novel epilepsy treatments for patients with tuberous sclerosis complex (TSC) and focal cortical dysplasia type II (FCDII) are urgently needed. In these patients, mutations in the mechanistic target of rapamycin (mTOR) pathway genes lead to mTOR hyperactivity and focal cortical malformations that frequently cause intractable epilepsy ...
Branden Stansley, Md. Monirul Islam, Dean J. Aguiar, Zoë Fuchs, Mackenzie Catron, Stephen Morairty, Ying Yuan, Radleigh Santos, Jingguo Hou, Annelies de Kater, George B. Thornton, Angelique Bordey   +11 more
wiley   +1 more source

Uncovering the mechanisms of synergistic drug combinations in non-small cell lung cancer through metagene-based classification. [PDF]

PLoS One
Lomloy C, Yamashita PR, Termsaithong T, Laomettachit T.   +3 more
europepmc   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

Insights From Mutational and Transcriptomic Profiles in Epithelial-myoepithelial Carcinoma. [PDF]

Am J Surg Pathol
Alsugair Z, Descotes F, Champagnac A, Lopez J, Fieux M, Philouse P, Céruse P, Thamphya B, Pissaloux D, Tirode F, Benzerdjeb N.   +10 more
europepmc   +1 more source

Aristolochic Acid and Hepatocellular Carcinoma: A Critical Review of Genotoxic and Inflammatory Mechanisms. [PDF]

Int J Mol Sci
Wang Y, Zhang Y, Ren T, Yuan L, Geng X.
europepmc   +1 more source

Hypoxic CAF studies unveil PTHrP‑vitamin D‑RAS axis as pivotal in the CAF. [PDF]

Oncol Rep
Nakajo S, Uemura M, Kusafuka H, Osaki M, Kusunoki C, Takiguchi N, Takeda M, Sekido Y, Hata T, Hamabe A, Ogino T, Miyoshi N, Tei M, Kagawa Y, Yamamoto H, Doki Y, Eguchi H.   +16 more
europepmc   +1 more source