Results 261 to 270 of about 211,660 (314)
Some of the next articles are maybe not open access.
2014
The three RAS genes (HRAS, KRAS, and NRAS) comprise the most commonly mutated oncogene family in human cancer. RAS genes encode highly related small GTPases that are key regulators of cytoplasmic signaling networks that include the Raf-MEK-ERK mitogen-activated protein kinase cascade and the PI3K-Akt signaling cascade. There is increasing evidence that
Tikvah K. Hayes +3 more
openaire +1 more source
The three RAS genes (HRAS, KRAS, and NRAS) comprise the most commonly mutated oncogene family in human cancer. RAS genes encode highly related small GTPases that are key regulators of cytoplasmic signaling networks that include the Raf-MEK-ERK mitogen-activated protein kinase cascade and the PI3K-Akt signaling cascade. There is increasing evidence that
Tikvah K. Hayes +3 more
openaire +1 more source
A novel ras-related gene family
Cell, 1985We have identified a new family of ras genes, the rho genes, which share several properties with the more classical ras gene family consisting of N-, K-, and H-ras. The rho genes, first isolated from a cDNA library from the abdominal ganglia of Aplysia, encode proteins that share 35% amino acid homology with H-ras. Evolutionarily conserved counterparts
P, Madaule, R, Axel
openaire +2 more sources
1995
Abstract Five ras genes (rasB, rasC, rasD, rasG and rasS) and one rap gene (rap1) have been isolated and characterized in the cellular slime mold Dictyostelium discoideum (Daniel etal. 1993,1994; Reymond etal. 1984; Robbins eta/. 1989,1990).
Juliet Daniel +2 more
openaire +1 more source
Abstract Five ras genes (rasB, rasC, rasD, rasG and rasS) and one rap gene (rap1) have been isolated and characterized in the cellular slime mold Dictyostelium discoideum (Daniel etal. 1993,1994; Reymond etal. 1984; Robbins eta/. 1989,1990).
Juliet Daniel +2 more
openaire +1 more source
H-RAS, K-RAS, and N-RAS Gene Activation in Human Bladder Cancers
Cancer Genetics and Cytogenetics, 2000Bladder cancer is one of the leading causes of cancer death in most developed countries. In this work, 19 bladder cancer specimens, along with their infiltrations of the urinary bladder wall from the same patients, were examined for the presence of H-RAS, K-RAS, and N-RAS activation using a polymerase chain reaction-restriction fragment length ...
B, Przybojewska +2 more
openaire +2 more sources
Pathology, research and practice, 1997
Ras gene mutations have been found with variable prevalence in different tumor types. While during the past decade a lot of information has been accumulated on the frequency of ras oncogene activation in tumors, the last two years brought considerable progress in elucidating molecular mechanisms of signal transduction for which cellular ras proteins ...
V, Waldmann, H M, Rabes
openaire +1 more source
Ras gene mutations have been found with variable prevalence in different tumor types. While during the past decade a lot of information has been accumulated on the frequency of ras oncogene activation in tumors, the last two years brought considerable progress in elucidating molecular mechanisms of signal transduction for which cellular ras proteins ...
V, Waldmann, H M, Rabes
openaire +1 more source
The Function of Ras Genes in Saccharomyces Cerevisiae
1990Publisher Summary This chapter describes the function of RAS genes in the yeast Saccharomyces cerevisiae and the components of the pathway in which it acts. Yeast RAS proteins share considerable homology with the mammalian RAS proteins. A short sequence including an invariant cysteine residue is always found at the carboxyl end of all RAS proteins ...
J R, Broach, R J, Deschenes
openaire +2 more sources
Different Patterns of Gene Expression in ras-Resistant and ras-Sensitive Cells
JNCI Journal of the National Cancer Institute, 1991We have shown previously that nontumorigenic NIH 3T3 cells can be made tumorigenic and metastatic by transfection and expression of activated ras, whereas in LTA cells, which are tumorigenic but nonmetastatic, the degree of malignancy is not altered by ras.
A B, Tuck +3 more
openaire +2 more sources
The ras gene family and human carcinogenesis
Mutation Research/Reviews in Genetic Toxicology, 1988It has been well established that specific alterations in members of the ras gene family, H-ras, K-ras and N-ras, can convert them into active oncogenes. These alterations are either point mutations occurring in either codon 12, 13 or 61 or, alternatively, a 5- to 50-fold amplification of the wild-type gene. Activated ras oncogenes have been found in a
openaire +2 more sources
1986
The ras gene family in mammalian cells consists of five closely related members: the Harvey and Kirsten ras genes (c-Ha-ras1 and c-Ki-ras2), an inactive pseudogene of each (c-Ha-ras2 and c-Ki-ras1; see Hall 1984) and the N-ras gene. There are also several distinctly related genes designated rho (ras-homologous; Madaule and Axel 1985).
openaire +1 more source
The ras gene family in mammalian cells consists of five closely related members: the Harvey and Kirsten ras genes (c-Ha-ras1 and c-Ki-ras2), an inactive pseudogene of each (c-Ha-ras2 and c-Ki-ras1; see Hall 1984) and the N-ras gene. There are also several distinctly related genes designated rho (ras-homologous; Madaule and Axel 1985).
openaire +1 more source
Cancer surveys, 1987
Members of the ras multigene family have been found in virtually all eukaryotes, from yeast to mammals. ras is required for normal cell growth in the yeast Saccharomyces cerevisiae and in at least some mammalian cells. These genes induce tumorigenic transformation of established NIH 3T3 cells by increased expression of a normal ras gene, certain point ...
D R, Lowy, B M, Willumsen
openaire +1 more source
Members of the ras multigene family have been found in virtually all eukaryotes, from yeast to mammals. ras is required for normal cell growth in the yeast Saccharomyces cerevisiae and in at least some mammalian cells. These genes induce tumorigenic transformation of established NIH 3T3 cells by increased expression of a normal ras gene, certain point ...
D R, Lowy, B M, Willumsen
openaire +1 more source