Results 71 to 80 of about 373,131 (211)
Artificial Cells, Nanomedicine, and Biotechnology, 2019 Background Ras-PI3K pathway aberrant activation plays an important role in the occurrence and development of osteosarcoma. This study investigated the functions of Ras-PI3K pathway specific activation on histone H2A phosphorylation at threonine 120 ...
Xianlun Xu, Hao Yu
doaj +1 more source
Вавиловский журнал генетики и селекции, 2017 The renin-angiotensin system (RAS) is one of the main systems regulating arterial pressure and water-salt homeostasis of the body and is involved in the pathogenesis of cardiovascular diseases.
L. O. Klimov +3 more
doaj +1 more source
An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development [PDF]
, 2007 Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer.
Elgort, Marc G. +7 more
core +2 more sources
Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]
, 2002 International ...
Burdon, Tom +2 more
core +1 more source
The effects of oncogenic Ras on the ocular lens [PDF]
, 2004 only availableRas is a small GTP-binding protein in the signal transduction machinery. In most cell types, activation of Ras by growth factors is essential for normal cell proliferation.
Thurmon, Kerri
core
RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]
, 2016 Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia +16 more
core +1 more source
Discover OncologyRectal adenocarcinoma (READ) is a common malignant tumor of the digestive tract. Growing studies have confirmed Ras GTPase-activating proteins are involved in the progression of several tumors.
Yun Xiao +7 more
doaj +1 more source
Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis
Cell Reports, 2014 RAS genes are among the most frequently mutated proto-oncogenes in cancer. However, how Ras stability is regulated remains largely unknown. Here, we report a regulatory loop involving the E3 ligase Nedd4-1, Ras, and PTEN.
Taoling Zeng +15 more
doaj +1 more source
Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells [PDF]
, 2015 Background: Androgens drive the onset and progression of prostate cancer (PCa) via androgen receptor (AR) signalling. The principal treatment for PCa is androgen deprivation therapy, although the majority of patients eventually develop a lethal castrate-
Craig N Robson +6 more
core +4 more sources
Mutations of RAS genes in endometrial polyps
Oncology Reports, 2019 Endometrial polyps are common, yet the molecular mechanisms underlying their formation and progression remain unclear. We examined gene mutations possibly related to the pathogenesis of endometrial polyps, as well as to their clinical features. Four premenopausal patients with endometrial polyps, who were not under drug treatment, were recruited. Whole
Takeda, Takashi +7 more
openaire +3 more sources