Results 71 to 80 of about 209,288 (267)

Biological aspects and tumorigenic activity of the Ras proto-oncogenic family
Aspectos biológicos e atividade tumorigênica da família proto-oncogênica Ras

Semina: Ciências Biológicas e da Saúde, 2010
Proto-oncogenes play an important role in the regulation of the cellular cycle, being critical to the tumorigenesis. In this category we can find the RAS family.
Juliano André Boquett, Reginaldo Justino Ferreira   +1 more
doaj  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Impeded Nedd4-1-Mediated Ras Degradation Underlies Ras-Driven Tumorigenesis

Cell Reports, 2014
RAS genes are among the most frequently mutated proto-oncogenes in cancer. However, how Ras stability is regulated remains largely unknown. Here, we report a regulatory loop involving the E3 ligase Nedd4-1, Ras, and PTEN.
Taoling Zeng, Qun Wang, Jieying Fu, Qi Lin, Jing Bi, Weichao Ding, Yikai Qiao, Sheng Zhang, Wenxiu Zhao, Huayue Lin, Meilin Wang, Binfeng Lu, Xianming Deng, Dawang Zhou, Zhenyu Yin, Hong-Rui Wang   +15 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

RAS diseases in children

Haematologica, 2014
RAS genes encode a family of 21 kDa proteins that are an essential hub for a number of survival, proliferation, differentiation and senescence pathways. Signaling of the RAS-GTPases through the RAF-MEK-ERK pathway, the first identified mitogen-associated
Charlotte M. Niemeyer
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Breast tumors with elevated expression of 1q candidate genes confer poor clinical outcome and sensitivity to Ras/PI3K inhibition.

PLoS ONE, 2013
Genomic aberrations are common in cancers and the long arm of chromosome 1 is known for its frequent amplifications in breast cancer. However, the key candidate genes of 1q, and their contribution in breast cancer pathogenesis remain unexplored.
Muthulakshmi Muthuswami, Vignesh Ramesh, Saikat Banerjee, Soundara Viveka Thangaraj, Jayaprakash Periasamy, Divya Bhaskar Rao, Georgina D Barnabas, Swetha Raghavan, Kumaresan Ganesan   +8 more
doaj   +1 more source

Effect Modification of Cigarette Smoking on the Relationship between Post‐traumatic Stress Disorder, Other Mental Health Conditions and Rheumatoid Arthritis Risk: A Large Case‐Control Study in U.S. Veterans

Arthritis Care &Research, Accepted Article.
Objective We examined associations of post‐traumatic stress disorder (PTSD) and other mental health disorders (OMH) with rheumatoid arthritis (RA), accounting for effects of smoking. Methods We conducted a matched case‐control study, identifying incident RA cases and controls using national Veteran Health Administration data (2006‐2019).
Kelsey Coziahr, Harlan Sayles, Tate M. Johnson, Joshua F. Baker, Punyasha Roul, Grant W. Cannon, Gary A. Kunkel, Katherine D. Wysham, Gail S. Kerr, Amir A. Razmjou, Isaac Smith, Jennifer L. Barton, Maria I. Danila, Jonathan S. Richards, Bryant R. England, Ted R. Mikuls   +15 more
wiley   +1 more source

Elucidating Ras protein as a dual therapeutic target for inflammation and cancer: a review

Discover Oncology
Cancer, one of the most dreadful diseases of the twenty-first century develops as a result of unregulated inflammatory responses and mutations of genes.
Parmar Keshri Nandan, Jayanthi Sivaraman
doaj   +1 more source

Ras-AKT signaling represses the phosphorylation of histone H1.5 at threonine 10 via GSK3 to promote the progression of glioma

Artificial Cells, Nanomedicine, and Biotechnology, 2019
Background Histone H1.5 has been considered as a novel cancer marker as its expression is associated with various human cancers. The objective of this study was to explore the effects of H1.5 phosphorylation in Ras-driven growth and migration of glioma ...
Ben Sang, Jianjing Sun, Dongxu Yang, Zhen Xu, Yuzhen Wei   +4 more
doaj   +1 more source