Results 111 to 120 of about 2,777,748 (307)

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Upstream regulator analysis in ipa identifying tumor necrosis alpha (TNF-α) as a major regulator of TBI-Dysregulated genes in the hippocampus.

, 2019
Upstream regulator analysis of hippocampal gene expression at 24 hr post-TBI (A). Upstream regulator analysis shows persistent dysregulation of genes predicted to be regulated by TNF-α 2 weeks post-injury in hippocampus (B).
Kathea M. Johnson (6551417), Douglas S. DeWitt (104666), Helen L. Hellmich (104660), Heidi Spratt (138802), Harris A. Weisz (745888), Donald S. Prough (104669), Michael T. Falduto (210155), Ian J. Bolding (6551414), Margaret A. Parsley (4503637), Deborah R. Boone (104664), Hannah E. Willey (6551411), Mala Sinha (248787), Karen E. O. Torres (663105)   +12 more
core   +1 more source

Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis [PDF]

, 2011
Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia.
Smith, H.E., Smith, H E, H. E. Smith, R. Goethe, Rohde, Manfred, Valentin-Weigand, P., M. Rohde, Goethe, R, J. Willenborg, Willenborg, J, de Greeff, A, Goethe, R., Willenborg, J., A. de Greeff, Valentin-Weigand, P, Greeff, A., De, P. Valentin-Weigand, Fulde, M., M. Fulde, Fulde, M, Rohde, M.   +20 more
core   +1 more source

Unveiling hypoxic regulatory networks by bioinformatics: mechanisms of hypoxia-related hub genes driving rituximab resistance and poor prognosis in DLBCL

Frontiers in Oncology
BackgroundDiffuse large B-cell lymphoma (DLBCL), an aggressive subtype of non-Hodgkin lymphoma, exhibits heterogeneous clinical outcomes. While rituximab, a CD20 inhibitor, combined with chemotherapy has improved survival in some patients, resistance ...
Jiayi Yao, Juan Huang, Juan Huang, Yuanfei Mao, Yuanfei Mao, Zizhen Xu   +5 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The Porphyromonas gingivalis ferric uptake regulator orthologue does not regulate iron homeostasis

Genomics Data, 2015
Porphyromonas gingivalis is a Gram-negative anaerobic bacterium that has an absolute requirement for iron which it transports from the host as heme and/or Fe2+. Iron transport must be regulated to prevent toxic effects from excess metal in the cell.
Catherine Butler, Helen Mitchell, Stuart Dashper, Eric Reynolds   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Prevalence of the fbs genes and of their regulator genes in a collection of 134 isolates belonging to the GBS major clonal complexes.

, 2013
Prevalence of the fbs genes and of their regulator genes in a collection of 134 isolates belonging to the GBS major clonal complexes.
Isabelle Virlogeux-Payant (122072), Agnès Rosenau (356790), Roland Quentin (20490), Rim Al Safadi (148712), Marie-Frédérique Lartigue (356787), Laurent Mereghetti (51436), Mazen Salloum (350905)   +6 more
core   +1 more source

Contribution of a Novel TetR/AcrR Family Transcriptional Regulator RalT of Ralstonia pseudosolanacearum Strain OE1‐1 to the Fine‐Tuning of Its Virulence

MicrobiologyOpen
During the quorum‐sensing (QS)‐active state, the Gram‐negative phytopathogenic Ralstonia pseudosolanacearum strain OE1‐1 activates the transcriptional regulator PhcA, regulating the QS‐dependent genes including ralfuranone production‐related genes such ...
Tatsuya Ueyama, Masayuki Tsuzuki, Sora Tateda, Yuki Terazawa, Aoi Ikeuchi, Akinori Kiba, Kouhei Ohnishi, Yasufumi Hikichi   +7 more
doaj   +1 more source