Results 91 to 100 of about 2,777,748 (307)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The evolution of gene regulation

eLife, 2017
The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
Veronica Hinman, Gregory Cary
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]

, 2004
The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J., Jaeger, S., Tempst, P., Puigserver, P., Fan, M., Handschin, C., St-Pierre, J., Spiegelman, B. M., Rhee, J., Erdjument-Bromage, H.   +9 more
core   +1 more source

Weighted gene co-expression network analysis unveils gene networks associated with the Fusarium head blight resistance in tetraploid wheat

BMC Genomics, 2019
Background Fusarium head blight (FHB) resistance in the durum wheat breeding gene pool is rarely reported. Triticum turgidum ssp. carthlicum line Blackbird is a tetraploid relative of durum wheat that offers partial FHB resistance.
Ehsan Sari, Adrian L. Cabral, Brittany Polley, Yifang Tan, Emma Hsueh, David J. Konkin, Ron E. Knox, Yuefeng Ruan, Pierre R. Fobert   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Transcriptional analysis of α-zein regulator genes.

, 2018
Quantitative RT-PCR analysis of α-zein regulator genes in 20-DAP endosperm. Gene expression was normalized to GRMZM2G023418. The first genotype in the cross is the seed parent. Data are representative of three biological replicates.
Raul Pirona (3686032), Iride Mascheretti (5979065), Aldo Ceriotti (3574151), Angelo Viotti (31102), Silvana Castelli (5979062), Barbara Lazzari (28788), Cristian Cosentino (31101), Massimiliano Lauria (3776968)   +7 more
core   +1 more source

Versatile regulation of effectors by novel orthologous regulators in the Legionella genus

mBio
The intracellular pathogen Legionella pneumophila utilizes the Icm/Dot type IVB secretion system, which translocates >300 effector proteins into host cells.
Chen Adler, Gil Segal
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Overlaps between genes regulated in the HIF-1 negative regulator mutants and genes regulated by HIF-1 under hypoxia.

Overlaps between genes regulated in the HIF-1 negative regulator mutants and genes regulated by HIF-1 under hypoxia.
Dingxia Feng (11105316), Jo Anne Powell-Coffman (11105319), Long Qu (120340)   +2 more
core   +1 more source