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Current Opinion in Genetics & Development, 2006
The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in animal development and physiology. Cellular activities such as proliferation, morphogenesis, apoptosis and differentiation are regulated by microRNAs.
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The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in animal development and physiology. Cellular activities such as proliferation, morphogenesis, apoptosis and differentiation are regulated by microRNAs.
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Journal of Endocrinology, 1988
Abstract Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham b15 2th received 1 November 1987 Introduction Thyrotrophin (TSH) is one of a family of glycoprotein hormones which includes the pituitary hormones ...
J A, Franklyn, M C, Sheppard
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Abstract Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham b15 2th received 1 November 1987 Introduction Thyrotrophin (TSH) is one of a family of glycoprotein hormones which includes the pituitary hormones ...
J A, Franklyn, M C, Sheppard
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Science, 2008
A video introduction focusing on RNA's role in gene regulation and the evolution of life.
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A video introduction focusing on RNA's role in gene regulation and the evolution of life.
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Differentiation and gene regulation
Current Opinion in Genetics & Development, 2007Reference UPDUB-ARTICLE-2007-003doi:10.1016/j.gde.2007.10.001View record in Web of Science Record created on 2008-02-25, modified on 2017-05 ...
Grosveld, F. G., Duboule, D.
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Histones as Regulators of Genes
Scientific American, 1992Histones were once dismissed as little more than packing material for nuclear DNA. In fact, these proteins can both repress and facilitate activation of many genes.
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Gene Regulation by Methylation
2009Epigenetic gene regulation of specific genes strongly affects clinical outcome of malignant glioma. MGMT is the best studied gene for the connection of promoter methylation and clinical course in glioblastoma. While MGMT promoter methylation analysis currently does not alter treatment of glioblastoma patients, mainly because of a lack of convincing ...
Wolf C, Mueller, Andreas, von Deimling
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Cellular and Molecular Life Sciences (CMLS), 1999
A recent explosion in the identification of new clock components in cyanobacteria, fungi, insects, mammals as well as potential candidates in plants has uncovered common themes among the structure, function and regulation of these components. Positive and negative interactions that are organized in negative feedback loops have been found crucial for ...
Y, Liu +3 more
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A recent explosion in the identification of new clock components in cyanobacteria, fungi, insects, mammals as well as potential candidates in plants has uncovered common themes among the structure, function and regulation of these components. Positive and negative interactions that are organized in negative feedback loops have been found crucial for ...
Y, Liu +3 more
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Gene Regulation in Spermatogenesis
2005Mammalian spermatogenesis is a complex hormone-dependent developmental program in which a myriad of events must take place to ensure that germ cells reach their proper stage of development at the proper time. Many of these events are controlled by cell type- and stage-specific transcription factors.
James A, Maclean, Miles F, Wilkinson
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Carotenoids and Gene Regulation
Nutrition Reviews, 2009Consumption of dietary carotenoids, plant pigments found in green, yellow, and orange fruits and vegetables, has been linked to decreased risk of cancer. Several intervention trials with beta-carotene, however, have failed to confirm this association. Indeed, in current smokers, beta-carotene appeared to increase risk. These disturbing results have not
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2016
Gene therapy represents a promising approach for the treatment of monogenic and multifactorial neurological disorders. It can be used to replace a missing gene and mutated gene or downregulate a causal gene. Despite the versatility of gene therapy, one of the main limitations lies in the irreversibility of the process: once delivered to target cells ...
Ludivine, Breger +3 more
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Gene therapy represents a promising approach for the treatment of monogenic and multifactorial neurological disorders. It can be used to replace a missing gene and mutated gene or downregulate a causal gene. Despite the versatility of gene therapy, one of the main limitations lies in the irreversibility of the process: once delivered to target cells ...
Ludivine, Breger +3 more
openaire +2 more sources