Results 141 to 150 of about 678,933 (267)

ELViS: an R package for estimating copy number levels of viral genomic segments at base-resolution. [PDF]

Bioinformatics
Lee JY, Holt JR, Zhao X, Hoadley KA, Hayes DN, Choi HY.   +5 more
europepmc   +1 more source

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Deep-sea viral diversity and their role in host metabolism of complex organic matter. [PDF]

Nat Commun
Wang C, Zheng R, Sun C.
europepmc   +1 more source

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials

Advanced Healthcare Materials, EarlyView.
The production of recombinant proteins represents a fundamental step in the characterisation of marine invertebrate adhesives and in the development of bio‐inspired glues. The association of these proteins with other components such as ions, proteins, polysaccharides, or polymers enables the fabrication of biomaterials for various healthcare ...
Alessandra Whaite, Emilie Duthoo, Mathilde Lefevre, Elise Hennebert, Patrick Flammang   +4 more
wiley   +1 more source

Molecular features of congenital cytomegalovirus infection in neonatal mouse brain at single-cell resolution. [PDF]

Acta Neuropathol Commun
Mei MJ, Zhou YP, Pan YT, Sun JY, Zeng WB, Wu T, McVoy MA, Britt WJ, Zhou W, Yang B, Jiang X, Rayner S, Cheng H, Luo MH.   +13 more
europepmc   +1 more source

Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are now emerging as promising biomaterials due to their inherent microporousity, injectability, and modularity. They have shown improvements in cell viability and migration, cellular/tissue infiltration, host tissue integration, mitigated foreign body response, and tissue regeneration.
Asmasadat Vaziri, Renata Maia, Pei Zhang, Liliana Agresti, Jelmer Sjollema, Mohammad‐Ali Shahbazi, Hélder A. Santos   +6 more
wiley   +1 more source

DNA viral community enhances microbial carbon fixation capacity via auxiliary metabolic genes in contaminated soils. [PDF]

Nat Commun
Lu JN, Chao Y, Tian L, Zhong X, Chen Z, He H, Huang B, Li M, Feng Z, Feng H, Hu C, Zhou S, Zhang L, Yang Y, Ruan Z, Ding K, Yang Y, Yuan K, Liu W, Qi H, Cao Y, Fei YH, Ling N, Wang S, Tang YT, Luan T, Xu Z, Qiu R.   +27 more
europepmc   +1 more source

Borate‐Ion‐Stimulated Macrophages Promote Osteogenic Differentiation of Mesenchymal Stem Cells

Advanced Healthcare Materials, EarlyView.
The immune responses of mouse macrophages stimulated by borate ions promote the osteogenic differentiation and mineralization of mouse bone marrow–derived mesenchymal stem cells in an ion‐dose‐dependent manner by providing cytokines, including BMP‐2.
Kazumasa Ikedo, Hiroki Hatakeyama, Sayaka Oguri, Akiko Obata, Toshihiro Kasuga   +4 more
wiley   +1 more source

Depth-driven decline in viral diversity unveils potential novel viruses in global deep-sea ecosystems. [PDF]

Microbiology (Reading)
Calderón-Osorno M, Rojas-Jimenez K.
europepmc   +1 more source