Results 191 to 200 of about 678,933 (267)

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Integrative genomic analyses support the division of the extended <i>Asfarviridae</i> clade into multiple viral families. [PDF]

J Virol
Mendonça-Santos T, Abrahão J, Del-Bem L-E.   +2 more
europepmc   +1 more source

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

Advanced Synthesis &Catalysis, EarlyView.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi, E. Alejandro Castellanos Franco, Connor J. Grady, Zinia Mohanta, Michael T. McMahon, Milana Bazayeva, Zhen Li, Kenneth M. Merz Jr., Assaf A. Gilad   +8 more
wiley   +1 more source

Codon usage of human DNA viruses and its similarity to certain host genes. [PDF]

Sci Rep
Sirihongthong T, Jitobaom K, Boonarkart C, Sheerazi K, Auewarakul P.   +4 more
europepmc   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

Advanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack, Urszula Orzeł, Anja Schlör, Sourabh Mehta, Anandi Krishnan, Slawomir Filipek, Rushika Patel, Madhvi Joshi, Markus Hoffmann, Stefan Pöhlmann, Chaitanya Joshi, Dorian Liepmann, Ramasamy Paulmurugan, Venkatesan Renugopalakrishnan   +13 more
wiley   +1 more source

Dancing with the enemy: symbiotic relationships between plant RNA viruses and their hosts. [PDF]

Front Plant Sci
Roy A, Bhattacharjee B, Hallan V.
europepmc   +1 more source

MMP2‐Responsive Liposomes Targeting LDLR Enhance the Effectiveness of Anti‐Cancer Drugs in Treating Melanoma

Advanced Therapeutics, EarlyView.
A bi‐functional liposomal system is developed to enhance melanoma therapy, combining mApoE‐mediated targeting of LDLR‐expressing tumor cells with MMP2‐responsive drug release. Loaded with Pimasertib, the liposomes improve intracellular delivery, reduce melanoma viability, and inhibit 3D spheroid growth and invasiveness.
Antonio Renda, Antonia I. Antoniou, Marika Quadri, Susanna Comi, Arianna Amenta, Silvia Sesana, Sara Pellegrino, Pierfausto Seneci, Marcus Koch, Vanna Denti, Giuseppe Paglia, Elisabetta Palazzo, Roberta Lotti, Alessandra Marconi, Francesca Re   +14 more
wiley   +1 more source

Integrative Roles of miRNAs and circRNAs in Plant Antiviral Gene Regulation and Autophagy. [PDF]

Plants (Basel)
Iksat N, Baikarayev Z, Shevchenko O, Zhanassova K, Bekturova A, Zhangazin S, Masalimov Z.   +6 more
europepmc   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source