Results 101 to 110 of about 919,210 (312)

H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation.

PLoS Genetics, 2012
The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites.
Anne Vielle, Jackie Lang, Yan Dong, Sevinc Ercan, Chitra Kotwaliwale, Andreas Rechtsteiner, Alex Appert, Q Brent Chen, Andrea Dose, Thea Egelhofer, Hiroshi Kimura, Przemyslaw Stempor, Abby Dernburg, Jason D Lieb, Susan Strome, Julie Ahringer   +15 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Identification of a sex-linked SNP marker in the salmon louse (Lepeophtheirus salmonis) using RAD sequencing [PDF]

, 2013
The salmon louse (Lepeophtheirus salmonis (Krøyer, 1837)) is a parasitic copepod that can, if untreated, cause considerable damage to Atlantic salmon (Salmo salar Linnaeus, 1758) and incurs significant costs to the Atlantic salmon mariculture ...
Carmichael, Stephen N, Bassett, David I, Stephen N. Carmichael, Bron, James, Christie, Hayden R. L., Skern-Mauritzen, Rasmus, Bekaert, Michaël, David I Bassett, James E Bron, John B. Taggart (208020), Rasmus Skern-Mauritzen, Bassett, David I., Gharb, Karim, Skuce, Philip J, Taggart John B., Bron, James E., Bron, James E, Hayden R. L. Christie (471364), David I. Bassett (471365), Bekaert Michaël, Sturm, Armin, Carmichael Stephen N., Stephen N Carmichael, Taggart, John B, Bassett, D I, Sturm Armin, John B. Taggart, James E. Bron (308427), Gharbi Karim, Hayden R. L. Christie, Christie, Hayden R L, John B Taggart, Skuce, Philip J., Skern-Mauritzen Rasmus, Hayden R L Christie, Skuce Philip J., Michaël Bekaert, Armin Sturm, Philip J Skuce, Karim Gharbi (432878), Karim Gharbi, Philip J. Skuce, Philip J. Skuce (471366), Bassett David I., Skuce, Phillip, David I. Bassett, Stephen N. Carmichael (471363), Taggart, John, James E. Bron, Christie Hayden R. L., Taggart, John B., Rasmus Skern-Mauritzen (457732), Michaël Bekaert (121005), Carmichael, Stephen N., Armin Sturm (93476), Gharbi, Karim, Bron James E., Bakaert, Michaël   +57 more
core   +1 more source

Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order

BMC Genomics, 2005
Background We generated the gene expression profile of the total testis from the adult C57BL/6J male mice using serial analysis of gene expression (SAGE). Two high-quality SAGE libraries containing a total of 76 854 tags were constructed.
Forejt Jiří, Pačes Václav, Strnad Petr, Vlček Čestmír, Divina Petr   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

X-linked mental deficiency.

, 2013
International audienceTen percent of cases of intellectual deficiency in boys are caused by genes located on the X chromosome. X-linked mental retardation (XLMR) includes more than 200 syndromes and 80 genes identified to date.
Des Portes, Vincent, Vincent des Portes
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice

Genome Biology, 2017
Background Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27me3, which marks many transcriptionally silent genes throughout the mammalian genome.
Emily Maclary, Michael Hinten, Clair Harris, Shriya Sethuraman, Srimonta Gayen, Sundeep Kalantry   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

X-Linked Genes Depend on MPK-1 for Germ Line Expression

, 2013
(A) Graph of mean changes in gene expression for X-linked genes in response to MPK-1 signaling. Blue indicates 19 MPK-1 signaling-responsive genes; pink indicates 52 additional X-linked genes with a mild response; and yellow indicates 104 X-linked genes ...
Stefanie W Leacock (274380), Valerie Reinke (52658)   +1 more
core   +1 more source