Results 281 to 290 of about 7,597,050 (334)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Pan-Epigenetic Age Prediction in Mammals. [PDF]

Aging Cell
Koch Z, Li A, Ideker T.
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Transcriptome analysis and RT-qPCR validation of mitophagy-related key genes in the progression of diabetic retinopathy. [PDF]

Front Endocrinol (Lausanne)
Zhang Y, Niu L, Xia H, Wang J.
europepmc   +1 more source

SARS-CoV-2 altered mitochondrial DNA methylation in Indian COVID-19 patients. [PDF]

Sci Rep
Kumari D, Singh S, Chauhan D, Dange K, Ganju L, Dogra V, Garg I, Srivastava S, Singh Y.   +8 more
europepmc   +1 more source

Reference Gene Stability in <i>Agrostemma githago</i> Using Quantitative Real-Time PCR. [PDF]

Int J Mol Sci
Bielecka M, Pencakowski B, Stafiniak M, Kozłowska W, Dziwak M, Nowis K, Łaczmański Ł, Matkowski A.   +7 more
europepmc   +1 more source

Auto-Sex Linkage in the Domestic Fowl: Modifiers of the Gene for Barred Feathers

, 2015
R. George Jaap
openalex   +1 more source