Results 91 to 100 of about 6,238,924 (364)
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Genetic Testing and Genetic Screening [PDF]
Kennedy Institute of Ethics Journal, 1993 In recent years there has been an enormous expansion in the knowledge that may be gleaned from the testing of an individual's genetic material to predict present or future disability or disease either for oneself or one's offspring. The Human Genome Project, which is currently mapping the entire human gene system, is identifying progressively more ...
openaire +3 more sources
Some genetic consequences of ice ages, and their role in divergence and speciation
, 1996 The genetic effects of pleistocene ice ages are approached by deduction from paleoenvironmental information, by induction from the genetic structure of populations and species, and by their combination to infer likely consequences.
G. Hewitt
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
HAPLOTYPES AND ALLELIC FREQUENCIES OF 12 Y-STR LOCI IN MONGOLIAN AND KOREAN MALE GROUPS
Proceedings of the Mongolian Academy of Sciences, 2017 Уг судалгааг “Монгол хүний Y хромосомын генетик мэдээллийн сан”, “Цэргийн албан хаагчдын генийн мэдээллийн сан бүрдүүлэх, туршилт судалгаа“ төслүүдийн хүрээнд хийж гүйцэтгэв.
Dashnyam B +4 more
doaj +1 more source
Population growth makes waves in the distribution of pairwise genetic differences.
Molecular biology and evolution, 1992 Episodes of population growth and decline leave characteristic signatures in the distribution of nucleotide (or restriction) site differences between pairs of individuals. These signatures appear in histograms showing the relative frequencies of pairs of
A. Rogers, H. Harpending
semanticscholar +1 more source
High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role?
Advanced Biomedical Research, 2012 Background: Despite elimination of iodine deficiency, the rates of both permanent and transient congenital hypothyroidism (CH) in our study were higher than the comparable worldwide rates, which emphasize the major role of genetic factors in the ...
Mahin Hashemipour +2 more
doaj +1 more source
Genetic consequences of climatic oscillations in the Quaternary.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2004 An appreciation of the scale and frequency of climatic oscillations in the past few million years is modifying our views on how evolution proceeds. Such major events caused extinction and repeated changes in the ranges of those taxa that survived.
G. Hewitt
semanticscholar +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Autosomal dominant tubulointerstitial kidney disease (ADTKD) in Ireland
Renal Failure, 2019 Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare genetic cause of renal impairment resulting from mutations in the MUC1, UMOD, HNF1B, REN, and SEC61A1 genes.
S. Cormican +18 more
doaj +1 more source