FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Clinical Case ReportsCerebral folate deficiency (CFD) is characterized by reduced levels of folate, particularly 5‐methyltetrahydrofolate (5‐MTHF), in the cerebrospinal fluid (CSF). This case report describes a 10‐year‐old girl diagnosed with CFD due to a pathogenic mutation
Farzad Ahmadabadi +4 more
doaj +1 more source
Long-Term Prognosis of Acute Myeloid Leukemia According to the New Genetic Risk Classification of the European LeukemiaNet Recommendations: Evaluation of the Proposed Reporting System [PDF]
, 2011 Christoph Röllig +16 more
openalex +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Misspecification in mixed-model based association analysis
, 2015 Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers.
Kruijer, Willem
core +2 more sources
Genetic Organization of Transposase Regions Surrounding bla KPC Carbapenemase Genes on Plasmids from Klebsiella Strains Isolated in a New York City Hospital [PDF]
, 2009 Thomas D. Gootz +6 more
openalex +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis
Frontiers in MicrobiologyBackgroundAndrogenetic alopecia (AGA) is the most common type of androgen-associated hair loss. Previous studies have indicated an association between the gut microbiota and AGA.
Haijing Fu +5 more
doaj +1 more source
Do Organic Consumers Oppose Genetically Modified Food Stronger than Others? Results of a Consumer Research in Germany [PDF]
, 2007 The majority of consumers, in particular European consumers oppose genetic modifi-cation of food. Although consumers oppose strongly genetic modification of food, genetically modified food production increases world wide.
Wirthgen, Antje
core
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source