Results 71 to 80 of about 6,238,924 (364)

Diferencias de sexo, edad y lípidos plasmáticos asociadas al polimorfismo de la apolipoproteína E en un grupo de escolares de Quindío, Colombia

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2009
Introducción. El polimorfismo de la apolipoproteína E (apoE) es un factor determinante genético de los niveles de colesterol total y colesterol LDL. Objetivo.
Nelsy Loango   +3 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Análisis del polimorfismo del gen APOE en la población de Barranquilla, Colombia

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2016
Introducción. La variabilidad genética del polimorfismo del gen APOE se considera un importante factor asociado a la predisposición a las enfermedades que afectan el metabolismo lipídico, a las enfermedades coronarias y a la enfermedad de Alzheimer ...
Martha Ruiz   +5 more
doaj   +1 more source

Idiopathic Subglottic Tracheal Stenosis in Identical Twin Sisters [PDF]

open access: yesIranian Journal of Otorhinolaryngology, 2019
Introduction: Idiopathic subglottic tracheal stenosis is a rare inflammatory disease of the trachea; most commonly affects females within the age range of 20-50 years.
Azizollah Abbasi Dezfuli   +2 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Climate change and epilepsy: Time to take action

open access: yesEpilepsia Open, 2019
Climate change is the biggest challenge facing humanity today. The associated global warming and humidification, increases in the severity and frequency of extreme climate events, extension of the ranges of vector‐borne diseases, and the consequent ...
Sanjay M. Sisodiya   +7 more
doaj   +1 more source

Spectrum and Frequency of Mutations Induced by Gamma Radiations in Three Varieties of Nigerian Sesame (Sesamum indicum L.)

open access: yesNotulae Scientia Biologicae, 2018
Insufficient genetic variability is one of the major problems of plant breeding programmes, especially in sesame. Gamma radiation has been reported to be very effective in creating genetic variability in plants.
Muhammad Liman MUHAMMAD   +5 more
doaj   +1 more source

Contrasting of Various Algorithmic Techniques to Solve Knapsack 0-1 Problem

open access: yesJOIV: International Journal on Informatics Visualization, 2020
This paper will point of convergence on a relative assessment and estimation of the dynamic programming, B&B, Greedy and Genetic algorithm including of the intricacy of time prerequisites, and the necessary programming endeavors and inspect the absolute ...
Yogesh Awasthi, Ashish Sharma
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

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