Results 111 to 120 of about 339,146 (264)

Dynamic genetic adaptation of Bacteroides thetaiotaomicron during murine gut colonization. [PDF]

Cell Rep, 2023
Kennedy MS, Zhang M, DeLeon O, Bissell J, Trigodet F, Lolans K, Temelkova S, Carroll KT, Fiebig A, Deutschbauer A, Sidebottom AM, Lake J, Henry C, Rice PA, Bergelson J, Chang EB.   +15 more
europepmc   +1 more source

Genetic Assimilation: Adaptation Versus Adaptability [PDF]

Evolution, 1956
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Genetic Adaptation of Siberian Larch (Larix sibirica Ledeb.) to High Altitudes. [PDF]

Int J Mol Sci, 2023
Novikova SV, Sharov VV, Oreshkova NV, Simonov EP, Krutovsky KV.   +4 more
europepmc   +1 more source

Parallel Adaptive Genetic Algorithm

, 1998
In this paper we introduce an efficient implementation of asynchronously parallel genetic algorithm with adaptive genetic operators. The classic genetic algorithm paradigm is extended with parallelization on one hand and an adaptive operators method on the other.
Budin, Leo, Golub, Marin, Jakobović, Domagoj   +2 more
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Genetic adaptation of skin pigmentation in highland Tibetans. [PDF]

Proc Natl Acad Sci U S A, 2022
Yang Z, Bai C, Pu Y, Kong Q, Guo Y, Ouzhuluobu, Gengdeng, Liu X, Zhao Q, Qiu Z, Zheng W, He Y, Lin Y, Deng L, Zhang C, Xu S, Peng Y, Xiang K, Zhang X, Baimayangji, Cirenyangji, Cui C, Baimakangzhuo, Gonggalanzi, Bianba, Pan Y, Xin J, Wang Y, Liu S, Wang L, Guo H, Feng Z, Wang S, Shi H, Jiang B, Wu T, Qi X, Su B.   +37 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Thermal Selection Shifts Genetic Diversity and Performance in Blue Mussel Juveniles

Evolutionary Applications
Exploring evolutionary and physiological responses to environmental stress is crucial for assessing the effects of climate change on wild populations.
Jennifer C. Nascimento‐Schulze, Jahangir Vajedsamiei, Tim P. Bean, Lisa Frankholz, Reid S. Brennan, Frank Melzner, Robert P. Ellis   +6 more
doaj   +1 more source

Whole-genome sequencing provides novel insights into the evolutionary history and genetic adaptation of reindeer populations in northern Eurasia. [PDF]

Sci Rep, 2023
Pokharel K, Weldenegodguad M, Dudeck S, Honkatukia M, Lindeberg H, Mazzullo N, Paasivaara A, Peippo J, Soppela P, Stammler F, Kantanen J.   +10 more
europepmc   +1 more source