Results 131 to 140 of about 339,146 (264)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Achromobacter spp. genetic adaptation in cystic fibrosis. [PDF]

Microb Genom, 2021
Gabrielaite M, Nielsen FC, Johansen HK, Marvig RL.   +3 more
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Genetic Adaptation of Mesorhizobium Symbionts Associated With Caragana in Northern China Deserts. [PDF]

Ecol Evol
Yuan X, Li H, Yu X, Ji Z.
europepmc   +1 more source

"What We Know and What We Do Not Know about Evolutionary Genetic Adaptation to High Altitude Hypoxia in Andean Aymaras". [PDF]

Genes (Basel), 2023
Amaru R, Song J, Reading NS, Gordeuk VR, Prchal JT.   +4 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Sperm, egg, and embryo proteins critical for genetic adaptation of herring to low salinity in the Baltic Sea. [PDF]

Proc Natl Acad Sci U S A
Ma C, Sangdehi FM, Kawaguchi M, Sano K, Dannenberg SV, Pettersson ME, Wallberg A, Wort JL, Yan Y, Moshkovskii S, Berg F, Folkvord A, Lenz C, Urlaub H, Kaupp UB, Yasumasu S, Andersson L.   +16 more
europepmc   +1 more source

Phenotypic but no genetic adaptation in zooplankton 24 years after an abrupt +10°C climate change. [PDF]

Evol Lett, 2022
Pais-Costa AJ, Lievens EJP, Redón S, Sánchez MI, Jabbour-Zahab R, Joncour P, Van Hoa N, Van Stappen G, Lenormand T.   +8 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Assessment of genome evolution in <i>Bifidobacterium adolescentis</i> indicates genetic adaptation to the human gut. [PDF]

mSystems
Selleri E, Tarracchini C, Petraro S, Mancabelli L, Milani C, Turroni F, Shao Y, Browne HP, Lawley TD, van Sinderen D, Ventura M, Lugli GA.   +11 more
europepmc   +1 more source