Results 31 to 40 of about 339,146 (264)

Culture is Reducing Genetic Heritability and Superseding Genetic Adaptation

Behavioral and Brain Sciences, 2021
Abstract Uchiyama et al. reveal how group-structured cultural variation influences measurements of trait heritability. We argue that understanding culture's influence on phenotypic heritability can clarify the impact of culture on genetic inheritance, which has implications for long-term gene–culture coevolution.
Wood, Zachary, Waring, Timothy, Xue, Mona   +2 more
openaire   +4 more sources

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Population Extinction and the Genetics of Adaptation [PDF]

The American Naturalist, 2008
Theories of adaptation typically ignore the effect of environmental change on population size. But some environmental challenges--challenges to which populations must adapt--may depress absolute fitness below 1, causing populations to decline. Under this scenario, adaptation is a race; beneficial alleles that adapt a population to the new environment ...
Orr, H. Allen, Unckless, Robert L.
openaire   +3 more sources

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Induction and phenotype analysis of autotetraploids of Morus Mongolica

BMC Plant Biology
Background Morus mongolica holds significant value in medicinal applications, livestock fodder production, and ecological restoration. Although polyploidization is well-documented in plants for enhancing stress tolerance and altering nutrient composition,
Juan Wang, Yanxuan Li, Yizhe Shi, Kexin Liu, Songlu Ran, Jingyu Cong, Guojing Li, Xiuzhi Ma, Yan Liang, Ruigang Wang   +9 more
doaj   +1 more source

Ecological adaptation in Atlantic herring is associated with large shifts in allele frequencies at hundreds of loci

eLife, 2020
Atlantic herring is widespread in North Atlantic and adjacent waters and is one of the most abundant vertebrates on earth. This species is well suited to explore genetic adaptation due to minute genetic differentiation at selectively neutral loci.
Fan Han, Minal Jamsandekar, Mats E Pettersson, Leyi Su, Angela P Fuentes-Pardo, Brian W Davis, Dorte Bekkevold, Florian Berg, Michele Casini, Geir Dahle, Edward D Farrell, Arild Folkvord, Leif Andersson   +12 more
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

The abiotic stress gene (Asg) family member Asg2 as a modulator of plant responses to salt stress

Plant Stress
The Abiotic Stress Gene (Asg) family, unique to plants, includes members with the DUF1005 domain of unknown function (DUFs). Although earlier studies have associated members of the Asg gene family and various aspects of plant growth, development, and ...
Xiaona Tian, Ziru Chang, Ruigang Wang, Guojing Li, Yang Qi   +4 more
doaj   +1 more source

Mechanism of floral scent production in Osmanthus fragrans and the production and regulation of its key floral constituents, β-ionone and linalool

Horticulture Research, 2019
Sweet osmanthus (Osmanthus fragrans Lour.) is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower.
Yuanji Han, Hongyun Wang, Xiaodan Wang, Ke Li, Meifang Dong, Yong Li, Qian Zhu, Fude Shang   +7 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source