Results 141 to 150 of about 232,851 (305)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The Iraqi Journal of Agricultural scienceThis study aimed to estimate variability and some genetic parameters for yield and yield components in pea (Pisum sativum L.) genotypes under different phosphorous levels.
Samar A. Yako, Payman A. A. Zibari
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Heritability and genetic advance among chili pepper genotypes for heat tolerance and morphophysiological characteristics. [PDF]
ScientificWorldJournal, 2014 Usman MG +4 more
europepmc +1 more source
Genetic-local hybrid optimizer for solving advance layout problem
, 2006 Advance Layout problem(ALP) is used to search for an optimal layout of machines. This research describes a novel method, based on genetic algorithms(GA) to solve the machine layout problem, where developing machine layout is an important step designing ...
Ibrahim Habra, Hind Saleem, Taha, Imad
core
A Procedure for Estimating Genetic Advance in a Multi-Site Trial [PDF]
, 1992 25 pages, 1 article*A Procedure for Estimating Genetic Advance in a Multi-Site Trial* (Federer, W.
Cornell University. Dept. of Biological Statistics and Computational Biology. +3 more
core
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
, 2015 A field study was carried out involving 10 parents and 45 F 1 ’s planted in RBD having three replications during 2011-2012. The analysis of genetic variability, heritability and genetic advance for fourteen quantitative traits viz., days to 50% flowering,
S. A. KERKHI, DINESH KUMAR
core