Results 251 to 260 of about 206,658 (295)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Identifying new targets in the fight against opioids. [PDF]

Elife
Laezza F.
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Estimating Genetic Variability and Heritability of Morpho-Agronomic Traits of M5 Cowpea (<i>Vigna unguiculata</i> (L.) Walp) Mutant Lines. [PDF]

Int J Mol Sci
Ramolekwa K, Pholo-Tait M, Parker T, Malambane G, Ngwako S, Lekgari L.   +5 more
europepmc   +1 more source

Estimation of genetic parameters in hybrid and F₂ generations of aromatic fine rice for breeding improvement. [PDF]

BMC Plant Biol
Tareque AMMMU, Hassan L, Habib MA, Nayak S, Robin AHK.   +4 more
europepmc   +1 more source

(Advanced Genetics 2/05)

Advanced Genetics
openaire   +2 more sources

The Paul Fearn Award for Excellence in Data Sharing in Cancer Control and Population Sciences. [PDF]

Cancer Epidemiol Biomarkers Prev
Daee D, Behm M, Marcus PM, Rosenfield SM, Rotunno M, Cronin KA, Kobrin SC, Gillanders EM.   +7 more
europepmc   +1 more source

Genetic Findings of Potential Donor Origin in Cells Used for Cell and Gene Therapy: Recommendations from the World Marrow Donor Association. [PDF]

Transplant Cell Ther
Pryce A, Cody M, Madbouly A, van Eerden E, Machin LL, Stefanski HE, Hatton D, Anthias C, Hernandez D, Bannon S, Mengling T, Allan DS.   +11 more
europepmc   +1 more source