Results 71 to 80 of about 527,936 (311)

An Improved NSGA-III Algorithm Using Genetic K-Means Clustering Algorithm

open access: yesIEEE Access, 2019
The non-dominated sorting genetic algorithm III (NSGA-III) has recently been proposed to solve many-objective optimization problems (MaOPs). While this algorithm achieves good diversity, its convergence is unsatisfactory.
Qingguo Liu   +3 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

STUDI PERBANDINGAN ANTARA ALGORITMA BIVARIATE MARGINAL DISTRIBUTION DENGAN ALGORITMA GENETIKA

open access: yesJurnal Informatika, 2006
Bivariate Marginal Distribution Algorithm is extended from Estimation of Distribution Algorithm. This heuristic algorithm proposes the new approach for recombination of generate new individual that without crossover and mutation process such as genetic ...
Chastine Fatichah   +2 more
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

An Improved Chaos Genetic Algorithm for T-Shaped MIMO Radar Antenna Array Optimization

open access: yesInternational Journal of Antennas and Propagation, 2014
In view of the fact that the traditional genetic algorithm easily falls into local optimum in the late iterations, an improved chaos genetic algorithm employed chaos theory and genetic algorithm is presented to optimize the low side-lobe for T-shaped ...
Xin Fu   +4 more
doaj   +1 more source

An Immune Genetic Algorithm for Multi-Echelon Inventory Cost Control of IOT Based Supply Chains

open access: yesIEEE Access, 2018
Internet of Things (IOT) is being widely used especially in industry sectors. The IOT techniques provide more information for the inventory control. With the increased fierce competition in market economy, the supply chain is at the core of a successful ...
Yingchen Wang   +3 more
doaj   +1 more source

The IFNγ‐CIITA‐MHC II axis modulates melanoma cell susceptibility to NK‐cell‐mediated cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Natural killer (NK) cells play a central role in anti‐melanoma immunity. However, melanoma cells adapt during co‐culture by upregulating CIITA and MHC II in response to interferon gamma (IFNγ), thereby evading NK‐cell lysis. Blocking IFNγ signaling or treatment with dimethyl fumarate/simvastatin counteracts this immune escape and maintains NK‐cell ...
Lena C. M. Krause   +6 more
wiley   +1 more source

基于小生境遗传算法的汽车悬架优化设计研究

open access: yesJixie chuandong, 2013
Improvements on the basis of traditional genetic algorithms,combined with the advantages of niche algorithm and genetic algorithm,a niche genetic algorithm for optimization of mechanical design is proposed.This algorithm is used in real machinery ...
常秋香
doaj  

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