Results 41 to 50 of about 3,829,483 (294)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Comparative analysis of the method of assignment by classes in GAVaPS

Journal of Computer Science and Technology, 2000
Three alternatives within the method of assignment by classes are presented for the calculation of individuals lifetime in genetic algorithms with varying population size. (GAVaPS). In the proposed strategy (assignment by classes) individuals are grouped
Laura Cristina Lanzarini, Cecilia Verónica Sanz, Marcelo Naiouf, Fernando Romero   +3 more
doaj  

UniSchedApi: A comprehensive solution for university resource scheduling and methodology comparison

TESEA, Transactions on Energy Systems and Engineering Applications
This paper introduces UniSchedApi, an API-based solution that revolutionizes optimized university resource scheduling. The primary focus of the research is the detailed evaluation of two automatic resource allocation methods: Tabu Search (TS) and ...
Alexandra La Cruz, Luis Herrera, Jeisson Cortes, Andrés García, Erika Severeyn   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

GENETIC ALGORITHMS OF WORK DISTRIBUTION

Вестник Донского государственного технического университета, 2018
The tasks of heterogeneous work distribution among heterogeneous executors taking into account operation and switching process costs are investigated. Genetic algorithms of work distribution that can be used for solving various practical tasks both in ...
Andrey R. Aidinyan, Olga L. Tsvetkova
doaj  

ASSESSING SOFTWARE RELIABILITY USING GENETIC ALGORITHMS

The Journal of Engineering Research, 2019
The role of software reliability and quality improvement is becoming more important than any other issues related to software development. To date, we have various techniques that give a prediction of software reliability like neural networks, fuzzy ...
Rachna Jain, Arun Sharma
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Local Crossover: A New Genetic Operator for Grammatical Evolution

Algorithms
The presented work outlines a new genetic crossover operator, which can be used to solve problems by the Grammatical Evolution technique. This new operator intensively applies the one-point crossover procedure to randomly selected chromosomes with the ...
Ioannis G. Tsoulos, Vasileios Charilogis, Dimitrios Tsalikakis   +2 more
doaj   +1 more source

Qualified Genetic Algorithms for Images Smoothing [PDF]

المجلة العراقية للعلوم الاحصائية, 2008
Four types of algorithms are suggested in this paper to smooth images; three of them work in the special domain and the fourth works in the frequency domain.
doaj   +1 more source