Results 51 to 60 of about 3,657,954 (286)

ASSESSING SOFTWARE RELIABILITY USING GENETIC ALGORITHMS

open access: yesThe Journal of Engineering Research, 2019
The role of software reliability and quality improvement is becoming more important than any other issues related to software development. To date, we have various techniques that give a prediction of software reliability like neural networks, fuzzy ...
Rachna Jain, Arun Sharma
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Local Crossover: A New Genetic Operator for Grammatical Evolution

open access: yesAlgorithms
The presented work outlines a new genetic crossover operator, which can be used to solve problems by the Grammatical Evolution technique. This new operator intensively applies the one-point crossover procedure to randomly selected chromosomes with the ...
Ioannis G. Tsoulos   +2 more
doaj   +1 more source

Qualified Genetic Algorithms for Images Smoothing [PDF]

open access: yesالمجلة العراقية للعلوم الاحصائية, 2008
Four types of algorithms are suggested in this paper to smooth images; three of them work in the special domain and the fourth works in the frequency domain.
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Optimizing Scheduling for Enhanced Efficiency in Cube Storage Warehouses: A Genetic Algorithm Approach Across Different Schemes

open access: yesIEEE Access
This study investigates the application of a Genetic Algorithm (GA) for optimizing scheduling in automated cube storage warehouses, focusing on enhancing logistics processing speed.
Won Yong Ha
doaj   +1 more source

Quantum Genetic Algorithms for Computer Scientists

open access: yesComputers, 2016
Genetic algorithms (GAs) are a class of evolutionary algorithms inspired by Darwinian natural selection. They are popular heuristic optimisation methods based on simulated genetic mechanisms, i.e., mutation, crossover, etc.
Rafael Lahoz-Beltra
doaj   +1 more source

Genetic Algorithm for Synchronization

open access: yes, 2009
We present a novel approach to the synchronization problem. It is a well-known fact that a problem of finding minimal (or: the shortest) synchronizing word (MSW) for a given synchronizing automaton is NP-complete. In this paper we present the genetic algorithm which tries, for a given automaton, to find possibly short word that synchronizes it.
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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