Results 171 to 180 of about 3,039,543 (317)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Correction: Molecular Genetic Analysis of 103 Sporadic Colorectal Tumours in Czech Patients. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

A Genetic Programming Approach to Geometrical Digital Content Modeling in Web Oriented Applications [PDF]

The paper presents the advantages of using genetic techniques in web oriented problems. The specific area of genetic programming applications that paper approaches is content modeling.
Dragos PALAGHITA
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Identification of Blood Pressure-Associated Metabolites by Integrating Metabolomic and Genetic Analysis. [PDF]

MedComm (2020)
Liu Y, Cheng C, Pan XF, Shao W, Zhou D, Zhu Y.   +5 more
europepmc   +1 more source

Genetic linkage analysis in the age of whole-genome sequencing

, 2015
For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However,
Ott, Jurg, Leal, Suzanne M., Wang, Jing
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Genomic profiling as a tool for differential diagnosis of patients with pediatric lung diseases and discovery of novel disease-causing genes and genetic variants

, 2019
Primary ciliary dyskinesia (PCD) is a rare disorder that affects lungs, reproductive organs and the internal organs laterality. The disease is inherited in autosomal recessive or X-linked manner. PCD is clinically and genetically heterogeneous disorder
Anđelković, Marina, Spasovski, Vesna, Skakić, Anita, Pavlović, Sonja, Minić, Predrag, Sovtić, Aleksandar   +5 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Phenotypic and genetic analysis of energy partitioning and feed efficiency in Atlantic salmon. [PDF]

Genet Sel Evol
Sonesson AK, Difford GF, Norris A, Hatlen B.   +3 more
europepmc   +1 more source