Results 171 to 180 of about 115,560 (262)

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Genetic ancestry proportion influences risk of adverse events from tuberculosis treatment in Brazil. [PDF]

Hum Genet
Piekos JA, Amorim G, Ridolfi F, Cordeiro-Santos M, Kritski AL, Figueiredo MC, Andrade BB, Santos AR, Haas DW, Sterling TR, Rolla VC, Velez Edwards DR, Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil consortium.   +12 more
europepmc   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Human genetic ancestry, <i>Mycobacterium tuberculosis</i> diversity, and tuberculosis disease severity in Dar es Salaam, Tanzania. [PDF]

Elife
Zwyer M, Xu ZM, Ross A, Hella J, Sasamalo M, Rotival M, Hiza HC, Rutaihwa LK, Borrell S, Reither K, Fellay J, Portevin D, Quintana-Murci L, Gagneux S, Brites D.   +14 more
europepmc   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Genetic ancestry influences body shape and obesity risk in Latin American populations. [PDF]

Sci Rep
Trujillo-Jiménez MA, Pérez LO, Paschetta C, Ramallo V, Ruderman A, Useglio M, Toledo-Margalef P, Morales L, Freire-Gómez C, Navarro P, De Azevedo S, Pazos B, Teodoroff T, Bortolini MC, Acuña-Alonzo V, Canizales-Quinteros S, Poletti G, Gallo C, Rothhammer F, Rojas W, Ruiz-Linares A, Gasaneo S, Gasaneo G, Rowlands A, Nepomnaschy P, Delrieux C, Gonzalez-José R.   +26 more
europepmc   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations. [PDF]

Cell Rep
Hu X, Huang J, Yuan J, Sun Y, Wang Y, Hu Z, Jiang J, Wang Z, Wang B, Long M, Maxwell KN, Fan Y, Tanyi JL, Montone KT, Li H, Kim SH, Nathanson KL, Rebbeck TR, Domchek SM, Vonderheide RH, Zhang L.   +20 more
europepmc   +1 more source

Material Before Morphology: Substrate‐Dependent Mechanical Tuning of Radular Teeth

Advanced Materials Interfaces, EarlyView.
Substrate‐dependent material tuning in Clausilia radular teeth. Closely related taxa retain a conserved gross tooth morphology, but differ in elemental composition and mechanical properties according to feeding substrate. Rock‐associated taxa show increased Ca–Si enrichment and higher stiffness and hardness, especially in the central radular region ...
Ida Lilienthal, Bernhard Hausdorf, Stanislav N. Gorb, Wencke Krings   +3 more
wiley   +1 more source

Flexible Wide Bandgap Electrode System for In situ Cell Sensing and Irreversible Electroporation

Advanced Materials Interfaces, EarlyView.
The paper reports the design and wafer‐level microfabrication of a long‐lived, flexible 3C‐SiC electrode capable of sensitive and in situ cell sensing, as well as electroporation ablation. The work demonstrates a biocompatible and durable electrode platform that can perform reliable electrical interfacing with biological tissues over extended periods ...
Minh Anh Huynh, Sharda Yadav, Tuan‐Khoa Nguyen, Nam‐Trung Nguyen   +3 more
wiley   +1 more source