Results 161 to 170 of about 2,748,088 (370)

The causal impact of smoking behavior on osteoarthritis: a Mendelian randomization analysis

Frontiers in Public Health
ObjectiveAlthough smoking and osteoarthritis (OA) have been linked in a number of studies, the exact cause of the association is still unknown and the conclusion is controversial. The purpose of this study was to use Mendelian randomization (MR) analysis
Qiang Xiao, Susu Dong, Yafen Tan, Xuan Zhang, Lu Yao, Qiuping Li, Tianli Wang   +6 more
doaj   +1 more source

Resistance to experimental autoimmune myasthenia gravis in genetically inbred rats. Association with decreased amounts of in situ acetylcholine receptor-antibody complexes. [PDF]

, 1988
G Biesecker, David Koffler
openalex   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Simple Algorithms to Calculate Asymptotic Null Distributions of Robust Tests in Case-Control Genetic Association Studies in R [PDF]

The case-control study is an important design for testing association between genetic markers and a disease. The Cochran-Armitage trend test (CATT) is one of the most commonly used statistics for the analysis of case-control genetic association studies ...
Gang Zheng, Wing Kam Fung, Yong Zang
core   +1 more source

Contribution of Rare and Common APOE Variants to Familial Hypercholesterolemia in Spanish Cohort

Cardiogenetics
Our aim was to determine whether rare APOE pathogenic variants (PV) and the common e2/e3/e4 polymorphism were associated with the risk of familial hypercholesterolemia (FH).
Lorena M. Vega-Prado, Daniel Vázquez-Coto, Francisco Villazón, Lorena Suárez-Gutiérrez, Ceferino Martínez-Faedo, Edelmiro Menéndez-Torre, María Riestra, Silvia González-Martínez, Gala Gutiérrez-Buey, Claudia García-Lago, Juan Gómez, Victoria Alvarez, Helena Gil, Rebeca Lorca, Eliecer Coto   +14 more
doaj   +1 more source

Implications of self-identified race, ethnicity, and genetic ancestry on genetic association studies in biobanks within health systems [PDF]

arXiv
Precision medicine aims to create biomedical solutions tailored to specific factors that affect disease risk and treatment responses within the population. The success of the genomics era and recent widespread availability of electronic health records (EHR) has ushered in a new wave of genomic biobanks connected to EHR databases (EHR-linked biobanks ...
arxiv  

Association studies between type 1 (insulin-dependent) diabetes and 27 genetic markers: Lack of association between type 1 diabetes and kidd blood group [PDF]

, 1983
Susan E. Hodge, Carol E. Anderson, Katherine Neiswanger, Rachel Rubin, R.S. Sparkes, M.C. Sparkes, Michol Crist, M. Anne Spence, Paul I. Terasaki, David L. Rimoin, Jerome I. Rotter   +10 more
openalex   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Involve Children and Parents in Clinical Studies

Clinical and Translational Science, 2020
Eric Vermeulen, Kim Karsenberg, Johanna H. van derLee, Saskia N. deWildt   +3 more
doaj   +1 more source

Genetic studies in multiple myeloma. II. Immunoglobulin allotype associations [PDF]

, 1985
Stephen H. Leech, Rebecca J. Brown, Moses S. Schanfield   +2 more
openalex   +1 more source