Results 161 to 170 of about 2,761,484 (346)

Credible genetic associations?

International journal of molecular epidemiology and genetics, 2011
The proliferation in genetic association studies, and the recurring failure of initially promising findings to robustly replicate, demonstrates the need for stringent standards to ensure the identification of credible associations. The Human Genome Epidemiology Network has recently published intermin guideliness on evidential criteria for genetic ...
openaire   +1 more source

Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care [PDF]

Xinjian Ye, Yijing Bai, Mengjun Li, Yuhang Ye, Yitong Chen, Bin Liu, Yuwei Dai, Shan Wang, Weiyi Pan, Zhiyong Wang, Yingying Mao, Qianming Chen   +11 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Exploring the Genetic Association and Genetic Architecture of Iridocyclitis and Extraocular Autoimmune Diseases. [PDF]

Transl Vis Sci Technol
Yuan F, Pu K, Li L, Song H.
europepmc   +1 more source

Genetic diversity, population structure and genome wide association studies for nutritional and agronomic traits in a Brazilian Mesoamerican bean panel

, 2020
Jessica Delfini De Paula Iácono
openalex   +1 more source

Association of Blood Pressure and Genetic Background With White Matter Lesions in Patients With Mild Cognitive Impairment [PDF]

, 2008
Samantha Galluzzi, Cristina Geroldi, Luisa Benussi, Roberta Ghidoni, Cristina Testa, Genoveffa Borsci, Matteo Bonetti, Dario Manfellotto, Giuseppe Romanelli, Roberto Zulli, Giuliano Binetti, Giovanni B. Frisoni   +11 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Observational and Genetic Association of Myelodysplastic Syndromes (MDS) and Autoimmune Diseases in Adults. [PDF]

Mediators Inflamm
Li Q, Guo Y, Xiao G, Song X, Wei Y, Gao W, Feng G, Zuo X, Shi X, Zhao H, Hu Y, Rebetz J, Semple E, Guo L, Semple JW, Peng J, Xu S.   +16 more
europepmc   +1 more source

Genetic associations of T cell cancer immune response with tumor aggressiveness in localized prostate cancer patients and disease reclassification in an active surveillance cohort [PDF]

, 2018
Qinchuan Wang, Justin R. Gregg, Jian Gu, Yuanqing Ye, David W. Chang, John W. Davis, Timothy C. Thompson, Jeri Kim, Christopher J. Logothetis, Xifeng Wu   +9 more
openalex   +1 more source

Genetic Associations with Weight Gain among South Africans who Initiated Dolutegravir-Containing and Tenofovir-Containing Regimens

, 2021
Zinhle Cindi, Gary Maartens, Yuki Bradford, François Venter, Simiso Sokhela, Nomathemba Chandiwana, David W. Haas, Phumla Sinxadi   +7 more
openalex   +2 more sources