Results 211 to 220 of about 8,825,337 (378)

Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease

Journal of the American Medical Association (JAMA), 2017
C. Emdin, A. Khera, P. Natarajan, D. Klarin, S. Zekavat, A. Hsiao, S. Kathiresan   +6 more
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

PHA-induced interferon in multiple sclerosis: association between gamma interferon and clinical and genetical variables

, 1989
S.S. Papiha, J. Boddy, D. F. Roberts, David Bates   +3 more
openalex   +1 more source

An Open Letter to the American Genetic Association: A Neglected Issue [PDF]

, 1996
Bruce Wallace
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

On the analysis of genetic association with long-read sequencing data. [PDF]

PLoS Genet
He G, Scherer SW, Strug LJ.
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Genetics of ANCA-associated vasculitides.

Cleveland Clinic Journal of Medicine, 2002
Coen A. Stegeman, A. Karok, Cornelis Kallenberg   +2 more
openaire   +4 more sources

The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies

Journal of the American Statistical Association, 2017
I. Barnett, R. Mukherjee, Xihong Lin
semanticscholar   +1 more source

Genetic association of intelligence with longevity in Drosophila melanogaster. [PDF]

PLoS One
Khan M, Lkhagva E, Kim HM, Zhai C, Siddiqui SH, Hong ST.   +5 more
europepmc   +1 more source