Results 251 to 260 of about 8,825,337 (378)

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Genetic Association of Primary Lung Cancer With Urological Cancers: A Bidirectional Mendelian Randomization Study and SEER Database Validation. [PDF]

Cancer Med
Zhou H, Feng Z, Zheng C, Xia L, Dai Z, Ai Z, Li Z, Liu K, Wang Y, Su N, Chen Z, Zhang J, Jin X.   +12 more
europepmc   +1 more source

Epidemiological and Genetic Associations of Activated Factor XII Concentration With Factor VII Activity, Fibrinopeptide A Concentration, and Risk of Coronary Heart Disease in Men [PDF]

, 2000
Francesco Paolo Zito, Felicity Drummond, Sarah R. Bujac, M. P. Esnouf, James H. Morrissey, Steve E. Humphries, George J. Miller   +6 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Association studies in psychiatric genetics [PDF]

Molecular Psychiatry, 1997
Michael John Owen, Peter McGuffin, Peter Holmans   +2 more
openaire   +3 more sources

Association between the Endogenous Retrovirus HRES-1 and Multiple Sclerosis in the United Kingdom – Evidence of Genetically Different Disease Subsets? [PDF]

, 2000
Henrik Berg Rasmussen, M. A. Kelly, D. A. Francis, J. Clausen   +3 more
openalex   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Association genetic studies in grape

, 2008
Association genetic methods, based on the exploitation of linkage disequilibrium (LD), are valuable tools for the dissection of complex traits. In many plant species, they indeed have shown their usefulness for the analysis of the genetic determinism of quantitative traits.
Le Cunff, Loic, Fournier Level, Alexandre, Doligez, Agnes, Fernandez, Lucie, Romieu, Charles, Torregrosa, Laurent, Ageorges, Agnes, Cheynier, Veronique, Souquet, Jean Marc, Terrier, Nancy, Vezzulli, Silvia, Constantini, Laura, Emmanuelli, Franscesco, Grando, Stella M., Micheletti, Diego, Troggio, Michela, Velasco, Riccardo, Canaguier, Aurelie, Moroldo, Marco, Adam-Blondon, Anne-Francoise, This, Patrice   +20 more
openaire   +2 more sources

Genetic Association of Lipids and Lipid-Lowering Drug Target Genes With Atopic Dermatitis: A Drug Target Mendelian Randomization Study. [PDF]

Health Sci Rep
Luo M, Lin J, Zhuo Q, Lin L, Han Y.
europepmc   +1 more source

Association of MHC and rheumatoid arthritis. Why is rheumatoid arthritis associated with the MHC genetic region? An introduction. [PDF]

, 2000
Rikard Holmdahl
openalex   +1 more source