Results 251 to 260 of about 2,761,484 (346)

Genetic Association of Primary Angle-Closure Glaucoma and Disease Progression. [PDF]

Clin Exp Ophthalmol
Liang YJ, Ling A, Chan PP, Yam JC, Pang CP, Tham CC, Chen LJ.   +6 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Overlap between COPD genetic association results and transcriptional quantitative trait loci. [PDF]

HGG Adv
Saferali A, Kim W, Chase RP, NHLBI TransOmics in Precision Medicine (TOPMed), Vollmers C, Silverman EK, Cho MH, Castaldi PJ, Hersh CP.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Genetic Association in the Pathophysiology of Degenerative Cervical Disc Disease: Defining Roles. [PDF]

Asian J Neurosurg
Maheshwari S, Kumar V, Dhatt SS, Dhillon MS, Prakash A, Medhi B, Prakash M.   +6 more
europepmc   +1 more source

Genetic association analysis between polymorphisms of HAIRY-AND-ENHANCER-OF SPLIT-7 and congenital scoliosis.

, 2015
Zuchao Gu, Guixing Qiu, Yu Zhang
openalex  

LASSO based Resample Model Averaging for Genetic Association Studies

, 2019
Jeremy Sabourin
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations. [PDF]

Genome Biol
Ma Y, Xu H, Li Y, Kim H, Xu LL, Miao L, Xu P, Mao F, Zhou XJ, Zhou W, Lee S, Zhang JF, Zhang P, Bi W.   +13 more
europepmc   +1 more source