Results 251 to 260 of about 8,691,632 (395)

Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study [PDF]

, 2000
Veikko Salomaa, James S. Pankow, Gerardo Heiss, B. Çakır, J H Eckfeldt, R. Curtis Ellison, Richard H. Myers, Kara M. Hiller, K. R. Brantley, T. L. Morris, Brent W. Weston   +10 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

A Phenome-Wide Mendelian Randomization and Colocalization Study Reveals Genetic Association Between PBC and Other Autoimmune Disorders. [PDF]

Can J Gastroenterol Hepatol
Shi S, Liu M, Gao H, Liu F, Song Y.
europepmc   +1 more source

The IL9R region contribution in asthma is supported by genetic association in an isolated population [PDF]

, 2000
Paula Kauppi, Tarja Laitinen, Vesa Ollikainen, Heikki Mannila, Lauri A. Laitinen, Juha Kere   +5 more
openalex   +1 more source

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Adapting PRISMA Guidelines to Enhance Reporting Quality in Genetic Association Studies: A Framework Proposal. [PDF]

Asian Pac J Cancer Prev
Nezameslami R, Nezameslami A, Mehdikhani B, Mosavi-Jarrahi A, Shahbazi A, Rahmani A, Masoudi A, Yeganegi M, Akhondzardaini R, Bahrami M, Aghili K, Neamatzadeh H.   +11 more
europepmc   +1 more source

Association between the Endogenous Retrovirus HRES-1 and Multiple Sclerosis in the United Kingdom – Evidence of Genetically Different Disease Subsets? [PDF]

, 2000
Henrik Berg Rasmussen, M. A. Kelly, D. A. Francis, J. Clausen   +3 more
openalex   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Association between genetic variation of the insulin receptor gene and essential hypertension in the Korean population [PDF]

, 2000
Byung Yong Kang, Ki Tae Kim, Hyun Seon Eo, Kyoung Ho Lee, Sung Soo Hong, Jung Hee Shin, Chung Choo Lee   +6 more
openalex   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source