Results 271 to 280 of about 2,718,862 (371)

Genomic Control, a New Approach to Genetic-Based Association Studies [PDF]

, 2001
Bernie Devlin, Kathryn Roeder, Larry Wasserman   +2 more
openalex   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, Volume 19, Issue 5, Page 1532-1545, May 2025.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

Genetic association of lipid-lowering drug target genes with pancreatic cancer: a Mendelian randomization study. [PDF]

Sci Rep
Su B, Fan Z, Wu J, Zhan H.
europepmc   +1 more source

Accounting for Unmeasured Population Substructure in Case-Control Studies of Genetic Association Using a Novel Latent-Class Model [PDF]

, 2001
Glen A. Satten, W. Dana Flanders, Quanhe Yang   +2 more
openalex   +1 more source

Plasma‐activated media selectively induces apoptotic death via an orchestrated oxidative stress pathway in high‐grade serous ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1170-1187, April 2025.
High‐grade serous ovarian cancer (HGSOC) is the most common and aggressive type of ovarian cancer with urgent need for new treatment strategies. This study evaluates plasma‐activated media (PAM) as a novel treatment for HGSOC, showing its ability to selectively induce oxidative stress and apoptosis in HGSOC cell lines, patient ascites cells and primary
Lorena T. Davies, Raja Ganesen, John Toubia, Sung‐Ha Hong, Sushil Kumar KC, Martin K. Oehler, Carmela Ricciardelli, Endre J. Szili, Nirmal Robinson, Melissa R. Pitman   +9 more
wiley   +1 more source

Absence of genetic association between insulin-like growth factors and esophageal cancer. [PDF]

Medicine (Baltimore)
Sun Z, Wang X.
europepmc   +1 more source

Loss of SETD2 in wild‐type VHL clear cell renal cell carcinoma sensitizes cells to STF‐62247 and leads to DNA damage, cell cycle arrest, and cell death characteristic of pyroptosis

Molecular Oncology, Volume 19, Issue 4, Page 1244-1264, April 2025.
Vulnerability to the small molecule STF‐62247 is observed in SETD2‐inactivated VHL‐positive clear cell renal cell carcinoma (ccRCC) cells. DNA damage and loss of CDC25A leads to cell cycle arrest in S phase. Cleavage of caspase‐3 (CASP3) and gasdermin E (GSDME) suggests cell death by pyroptosis.
Mathieu Johnson, Sandra Turcotte
wiley   +1 more source

Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer. [PDF]

Front Med (Lausanne)
Zhao J, Zhang Y, Li J, Li Q, Teng Z.
europepmc   +1 more source

Unraveling epigenetic heterogeneity across gastrointestinal adenocarcinomas through a standardized analytical framework

Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.
This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto, Hege Marie Vedeld, Guro Elisabeth Lind, Marine Jeanmougin   +3 more
wiley   +1 more source

Unraveling the genetic association between knee osteoarthritis and hallux deformities. [PDF]

J Orthop Surg Res
Lv Z, Lin M, Zhang J, Sun K, Lin Z, Yin F, Huang J, Ye Y.   +7 more
europepmc   +1 more source