Results 81 to 90 of about 8,691,632 (395)

Polygenic Risk Score Prediction for Endometriosis

Frontiers in Reproductive Health, 2021
Endometriosis is a major health care challenge because many young women with endometriosis go undetected for an extended period, which may lead to pain sensitization.
Kirstine Kloeve-Mogensen, Kirstine Kloeve-Mogensen, Palle Duun Rohde, Palle Duun Rohde, Simone Twisttmann, Marianne Nygaard, Kristina Magaard Koldby, Rudi Steffensen, Christian Møller Dahl, Dorte Rytter, Michael Toft Overgaard, Axel Forman, Lene Christiansen, Lene Christiansen, Mette Nyegaard, Mette Nyegaard   +15 more
doaj   +1 more source

Genetic modifiers of cognitive maintenance among older adults. [PDF]

, 2014
ObjectiveIdentify genetic factors associated with cognitive maintenance in late life and assess their association with gray matter (GM) volume in brain networks affected in aging.MethodsWe conducted a genome-wide association study of ∼2.4 M markers to ...
Coppola, Giovanni, Evans, Daniel S, Kramer, Joel H, Tranah, Gregory J, Yaffe, Kristine, Yokoyama, Jennifer S   +5 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Progress in Genetic Studies of Tourette’s Syndrome

Brain Sciences, 2017
Tourette’s Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time.
Yanjie Qi, Yi Zheng, Zhanjiang Li, Lan Xiong   +3 more
doaj   +1 more source

GemTools: A fast and efficient approach to estimating genetic ancestry [PDF]

, 2011
To uncover the genetic basis of complex disease, individuals are often measured at a large number of genetic variants (usually SNPs) across the genome. GemTools provides computationally efficient tools for modeling genetic ancestry based on SNP genotypes.
Devlin, Bernie, Kent, Brian P., Klei, Lambertus, Melhem, Nadine, Roeder, Kathryn   +4 more
core  

Graphical chain models for the analysis of complex genetic diseases: an application to hypertension [PDF]

, 2002
A crucial task in modern genetic medicine is the understanding of complex genetic diseases. The main complicating features are that a combination of genetic and environmental risk factors is involved, and the phenotype of interest may be complex ...
Di Serio, C., Vicard, P.
core   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations

Genetics and Molecular Biology, 2017
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors.
Lixia Yu, Xiaoai Zhang, Yun Zhai, Hongxing Zhang, Wei Yue, Xiumei Zhang, Zhifu Wang, Hong Zhou, Gangqiao Zhou, Feng Gong   +9 more
doaj   +1 more source

Weak Association Between the Glutamate Decarboxylase 1 Gene (GAD1) and Schizophrenia in Han Chinese Population

Frontiers in Neuroscience, 2021
ObjectivesSchizophrenia (SZ) is a complex psychiatric disorder with high heritability, and genetic components are thought to be pivotal risk factors for this illness. The glutamate decarboxylase 1 gene (GAD1) was hypothesized to be a candidate risk locus
Luwen Zhang, Luwen Zhang, Luwen Zhang, Zhen Li, Zhen Li, Zhen Li, Qing Liu, Qing Liu, Qing Liu, Minglong Shao, Minglong Shao, Minglong Shao, Fuping Sun, Fuping Sun, Fuping Sun, Xi Su, Xi Su, Xi Su, Meng Song, Meng Song, Meng Song, Yan Zhang, Yan Zhang, Yan Zhang, Minli Ding, Yanli Lu, Jiewei Liu, Yongfeng Yang, Yongfeng Yang, Yongfeng Yang, Ming Li, Ming Li, Ming Li, Wenqiang Li, Wenqiang Li, Wenqiang Li, Luxian Lv, Luxian Lv, Luxian Lv, Luxian Lv   +39 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source