Results 91 to 100 of about 11,195,425 (262)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

gap: Genetic Analysis Package [PDF]

A preliminary attempt at collecting tools and utilities for genetic data as an R package called gap is described. Genomewide association is then described as a specific example, linking the work of Risch and Merikangas (1996), Long and Langley (1997) for
Jing Hua Zhao
core  

Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control

BMC Research Notes, 2018
Objective Clinical research on gene therapy has advanced the field of veterinary medicine, and gene doping, which is the illegal use of gene therapy, has become a major concern in horseracing. Since the International Federation of Horseracing Authorities
Teruaki Tozaki, Kaoru Karasawa, Yohei Minamijima, Hideaki Ishii, Mio Kikuchi, Hironaga Kakoi, Kei-ichi Hirota, Kanichi Kusano, Shun-ichi Nagata   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

FTO Polymorphisms are Associated with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Susceptibility in the Older Chinese Han Population

Clinical Interventions in Aging, 2020
Zhan Gu,1,* Yan Bi,2,* Fan Yuan,2,* Ruirui Wang,1 Dong Li,3 Jianying Wang,1 Xiaojuan Hu,1 Guang He,2 Lei Zhang,1 Bao-cheng Liu1 1Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203 ...
Gu Z, Bi Y, Yuan F, Wang R, Li D, Wang J, Hu X, He G, Zhang L, Liu B   +9 more
doaj  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations [PDF]

, 2009
Sphingolipids have essential roles as structural components of cell membranes and in cell signalling, and disruption of their metabolism causes several diseases, with diverse neurological, psychiatric, and metabolic consequences.
S. Campbell, Aulchenko, Y.S. (Yurii), Igl, Wilmar,, Zaboli, Ghazal, Polasek, O. (Ozren), A. Wright, J. F. Wilson, Gyllensten, U, Hicks, Andrew A, Schwienbacher, C, Hengstenberg, Christian, I. R. König, Peter Ugocsai, A. Demirkan, C. Pattaro, Wichmann, H.-E., G. Liebisch, Peters, Annette, Kirichenko, Anatoly V, Liebisch, G, Peters, A. (Annette), Witteman, Jacqueline C. M., Wright, Alan, C. Hengstenberg, O. Polasek, König, Inke R, P. Ugocsai, Janssens, A. Cecilej W., Hayward, C., Campbell, Harry, Campbell, H, Pichler, I. (Irene), Pichler, I., Gerhard Liebisch, Demirkan, A., Campbell, S, Biloglav, Z. (Zrinka), P. P. Pramstaller, Kolcic, I, Johansson, Asa, Liebisch, Gerhard, C. M. van, Wichmann, H.E. (Heinz Erich), Janssens, A Cecilej W, Meitinger, T., Wild, SH, Ozren Polasek, Igl, W., Jeanette Erdmann, Schmitz, G, Franklin, CS, S. Schreiber, Jonasson, I, Wichmann, H-Erich, Ugocsai, P, Polsek, Ozren, Wichmann, H.-Erich, Cornelia M van Duijn, Hengstenberg, C, Erdmann, J. (Jeanette), H. Campbell, König, I.R. (Inke), Axenovich,T.I., G. Schmitz, Y. Aulchenko, S. H. Wild, Schreiber, Stefan, Gyllensten, Ulf,, Campbell, Harry; id_orcid, I. Rudan, G. Zaboli, Schreiber, S., Ivana Kolcic, Johansson, A, Wright, A, Franklin, Christopher S, Kolcic, I., Zorkoltseva, I.V. (Irina), Wilson, J.F., Rudan, I. (Igor), Johansson, A. (Åsa), Zorkoltseva, I.V., Schwienbacher, Christine, Duijn, Cornelia, Marroni, Fabio, Witteman, Jacqueline C M, Fabio Marroni, Zaboli, Ghazal,, Jonasson, Inger, Hicks, A.A. (Andrew), Irene Pichler, Gyllensten, U., Campbell, H., Wichmann, HE, A Cecilej W Janssens, Pramstaller, P.P. (Peter Paul), Janssens, A.C., Peters, A., Wild, S.H., Isaacs, A., Pichler, Irene, Vitart, Veronique, N. Hastie, Tatiana I Axenovich, Johansson, Åsa,, I. Kolcic, Ghazal Zaboli, James F Wilson, Kolcic, I. (Ivana), Wilson, James F; id_orcid, Biloglav, Zrinka, Ugocsai, P. (Peter), Gnewuch, C., A. Johansson, Zaboli, G., Marroni, F, Andrew A Hicks, Pattaro, C., Pichler, I, Christian Hengstenberg, Jacqueline C M Witteman, Schunkert, H, Biloglav, Z, Caroline Hayward, Pattaro, Cristian, C. Hayward, Koenig, Inke R., Zrinka Biloglav, Demirkan, A. (Ayşe), Liebisch, G., J. Erdmann, Franklin, C.S. (Christopher), I. V. Zorkoltseva, U. Gyllensten, Alan Wright, Pattaro, C, Franklin, Christopher S., Hengstenberg, C. (Christian), A. V. Kirichenko, Harry Campbell, Schunkert, H., W. Igl, Hastie, N., Ulf Gyllensten, C. Schwienbacher, Kirichenko, AV, Demirkan, Ayse, Janssens, A. CecileJ.W., Schreiber, S, Wild, S.H. (Sarah), Zorkoltseva, IV, Schwienbacher, C. (Christine), Erdmann, Jeanette, Yurii Aulchenko, Asa Johansson, Ben A Oostra, Aulchenko, Y., Veronique Vitart, Liebisch, G. (Gerhard), B. A. Oostra, Janssens, Cecile, Christine Schwienbacher, Hastie, N, A. C. W, Rudan, Igor, Igl, W. (Wilmar), I. Pichler, Erdmann, J., C. Gnewuch, Konig, IR, Anatoly V Kirichenko, Schwienbacher, C., van Duijn, C.M., Jonasson, I., Kirichenko, A.V. (Anatoly), Schmitz, G., Hicks, Andrew A., A. A. Hicks, Susan Campbell, Annette Peters, Gerd Schmitz, Hayward, Caroline, Zorkoltseva, Irina V, Witteman, JCM, T. I. Axenovich, Gnewuch, C, König, I.R., Carsten Gnewuch, H. Wichmann, Gyllensten, Ulf, Igl, Wilmar, Meitinger, T, Kirichenko, Anatoly V., H-Erich Wichmann, Cristian Pattaro, C. S. Franklin, Gnewuch, Carsten, König, Inke R., Isaacs, A.J. (Aaron), Erdmann, J, Zaboli, G. (Ghazal), Christopher S Franklin, Campbell, S., Irina V Zorkoltseva, Zorkoltseva, Irina V., Hengstenberg, C., Zaboli, G, Hicks, A.A., Peter P Pramstaller, Marroni, F. (Fabio), Sarah H Wild, Ayse Demirkan, Johansson, A., Wright, A., Hicks, AA, Wichmann, Heinz-Erich, Nick Hastie, Hastie, Nick, H. Schunkert, Polasek, Ozren, Janssens, A. Cecile J. W., Inger Jonasson, Axenovich, TI, Polasek, O., Peters, A, Oostra, Ben A., Oostra, B.A., Wright, A.F. (Alan), Axenovich, T.I. (Tatiana), van Duijn, Cornelia M., Heribert Schunkert, Vitart, V. (Veronique), Hastie, N. (Nick), Wild, Sarah H; id_orcid, Schmitz, Gerd, Hayward, C. (Caroline), Biloglav, Z., Schunkert, H. (Heribert), Campbell, S. (Susan), A. Peters, Ugocsai, Peter, T. Meitinger, Oostra, Ben, Inke R König, Kolcic, Ivana, Stefan Schreiber, Gibson, Greg, Schunkert, Heribert, Z. Biloglav, Rudan, I., Isaacs, Aaron, V. Vitart, Tikka-Kleemola, P. (Päivi), Wilson, JF, Oostra, B.A. (Ben), Franklin, C.S., Jonasson, I. (Inger), Wilson, James F., Schreiber, S. (Stefan), Pramstaller, Peter P, Rudan, I, Wild, Sarah H., Schmitz, G. (Gerd), Janssens, A.C.J.W. (Cécile), Oostra, Ben A, Vitart, V, Meitinger, Thomas, Vitart, V., Aulchenko, Yurii, Pramstaller, PP, Gnewuch, C. (Carsten), Marroni, F., Campbell, Susan, Axenovich, Tatiana I., Hayward, C, Witteman, J.C.M. (Jacqueline), J. C. M, Wilmar Igl, Igl, W, Axenovich, Tatiana I, Kirichenko, A.V., Aulchenko, Yuriy, Wilson, J.F. (James), Gyllensten, U. (Ulf), van Duijn, Cornelia M, Meitinger, T. (Thomas), Hayward, Caroline; id_orcid, Thomas Meitinger, Ugocsai, P., Pattaro, C. (Cristian), Polasek, O, I. Jonasson, Pramstaller, Peter P., Aaron Isaacs, Igor Rudan, Witteman, J.C., Jonasson, Inger,, A. Isaacs, Pramstaller, P.P., Wild S. H., Schmitz G., Hastie Nick, Schreiber S., Campbell Susan, Peters Annette, Erdmann Jeanette, Wright A., Oostra B. A., Vitart Veronique, Zorkoltseva I. V, Witteman J. C., Johansson A, Zaboli Ghazal, Schreiber Stefan, Ugocsai P, König I. R., Pichler I., Liebisch Gerhard, Aulchenko Y, Hastie N., Pattaro C, Wild Sarah H., Zaboli G., Aulchenko Yurii, Isaacs A., Wichmann H. E., Hicks, AA;Pramstaller, PP;Johansson, Å;Vitart, V;Rudan, I;Ugocsai, P;Aulchenko, Y;Franklin, CS;Liebisch, G;Erdmann, J;Jonasson, I;Zorkoltseva, IV;Pattaro, C;Hayward, C;Isaacs, A;Hengstenberg, C;Campbell, S;Gnewuch, C;Janssens, AC;Kirichenko, AV;König, IR;Marroni, F;Polasek, O;Demirkan, A;Kolcic, I;Schwienbacher, C;Igl, W;Biloglav, Z;Witteman, JC;Pichler, I;Zaboli, G;Axenovich, TI;Peters, A;Schreiber, S;Wichmann, HE;Schunkert, H;Hastie, N;Oostra, BA;Wild, SH;Meitinger, T;Gyllensten, U;van Duijn, CM;Wilson, JF;Wright, A;Schmitz, G;Campbell, H, Schmitz Gerd, Kolcic Ivana, Campbell S., Schunkert H., Gyllensten U., Franklin Christopher S., Demirkan A., Liebisch G, Axenovich T. I., Rudan Igor, Witteman Jacqueline C. M., Wichmann H.-Erich, Hengstenberg Christian, Pramstaller PP, van Duijn Cornelia M., Oostra Ben A., Rudan I, Vitart V, Kolcic I., Ugocsai Peter, Gnewuch C., Franklin CS, Gyllensten Ulf, Biloglav Zrinka, Wilson James F., Igl Wilmar, Marroni F., Schunkert Heribert, van Duijn C. M., Zorkoltseva Irina V., Meitinger T., Meitinger Thomas, Kirichenko Anatoly V., Pichler Irene, Janssens A. C., Campbell H., Jonasson Inger, Biloglav Z., Peters A., Johansson Åsa, Hicks Andrew A., Demirkan Ayse, Isaacs Aaron, Hayward C., Hayward Caroline, Jonasson I, Kirichenko A. V., Erdmann J, Igl W., Schwienbacher Christine, Axenovich Tatiana I., Marroni Fabio, Polasek O., Pramstaller Peter P., Janssens A. CecileJ.W., Hicks AA, Pattaro Cristian, Polasek Ozren, Wilson J. F., Wright Alan, Gnewuch Carsten, Campbell Harry, Hengstenberg C., König Inke R.   +390 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Metabolic syndrome in inflammatory bowel disease: Association with genetic markers of obesity and inflammation

, 2019
Metabolic syndrome (MS) and inflammatory bowel disease (IBD) share common pathophysiological features including chronic inflammation in visceral adipose tissue. However, the interplay of these two pathologies is still unraveled.
Stanković, Biljana, Klaassen, Kristel, Dragašević, Sanja, Kotur, Nikola, Pavlović, Sonja, Sržentić Drazilov, Sanja, Popović, Dragan   +6 more
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source