Results 81 to 90 of about 11,195,425 (262)

Genome-Wide Association Studies of Asthma in Population-Based Cohorts Confirm Known and Suggested Loci and Identify an Additional Association near HLA [PDF]

open access: yes, 2012
Rationale: Asthma has substantial morbidity and mortality and a strong genetic component, but identification of genetic risk factors is limited by availability of suitable studies.
Palmer Cameron D.   +353 more
core   +3 more sources

Immune-checkpoint HLA-G gene polymorphisms, 3’-UTR types and their association with hepatocellular carcinoma and treatment response in Indian population

open access: yesFrontiers in Immunology
BackgroundHuman leukocyte antigen-G (HLA-G) is a cancer-associated immune checkpoint protein implicated in tumor-driven immune escape mechanisms. This study was undertaken to determine genetic variations at the 3’-UTR of the HLA-G gene that may alter its
Neeti Nadda   +9 more
doaj   +1 more source

Evaluation of the Association of Htr2a Gene Rs6313 Polymorphism with Heroin Dependence in a Sample from Northwest Iran

open access: yesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021
Introduction: Heroin dependence is a chronic relapsing disorder caused by a combination of genetic, epigenetic, and environmental factors. The genetic contribution in the vulnerability to heroin dependence is 40%-60%. Alterations in dopamine transport in
Fatemeh Mahmoudi   +3 more
doaj  

INTERLEUKIN 28 RECEPTOR GENE ALPHA IL28RA AND PSORIASIS: ASSOCIATION WITH DISEASE SEVERITY AND AGE AT ONSET

open access: yesМедицинская иммунология, 2016
Molecular basis still remains unclear for psoriasis, a chronic inflammatory skin disease. It biological features are presented by abnormal differentiation of epidermal keratinocytes, overgrowth and dilation of blood vessels, and leukocyte infiltration of
E. S. Galimova, E. K. Khusnutdinova
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Simple Algorithms to Calculate Asymptotic Null Distributions of Robust Tests in Case-Control Genetic Association Studies in R [PDF]

open access: yes
The case-control study is an important design for testing association between genetic markers and a disease. The Cochran-Armitage trend test (CATT) is one of the most commonly used statistics for the analysis of case-control genetic association studies ...
Wing Kam Fung, Yong Zang, Gang Zheng
core  

5-HTR1A and 5-HTR2A genetic polymorphisms and SSRI antidepressant response in depressive Chinese patients

open access: yesNeuropsychiatric Disease and Treatment, 2016
Zai-Quan Dong,1,* Xi-Rong Li,2,* Lin He,3,4 Guang He,3,4 Tao Yu,3,4 Xue-Li Sun1 1Psychological Center, West China Hospital, Sichuan University, Chengdu, Sichuan, 2Mental Health Center, First Affiliated Hospital, Chongqing Medical University, Chongqing ...
Dong Z, Li X, He L, He G, Yu T, Sun X
doaj  

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Common Genetic Variation and the Control of HIV-1 in Humans [PDF]

open access: yes, 2009
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects.
Cirulli, Elizabeth T   +319 more
core   +2 more sources

Heritability estimates of the position and number of facial hair whorls in Thoroughbred horses

open access: yesBMC Research Notes, 2019
Objective According to oral traditions of horse caretakers and trainers, the differences in the position and number of facial hair whorls may be associated with temperamental traits.
Tamu Yokomori   +7 more
doaj   +1 more source

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