Results 61 to 70 of about 226,034 (265)

Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data [PDF]

, 2011
Background Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease ...
Artitaya Lophatananon, Judith A Clements, Lophatananon, A, Rahman, Aneela, Marquart, Louise, Joanne Aitken, Kenneth Muir, Kedda, M A, Alexander, K, Gardiner, Robert A., Carson Stephens, Easton, Douglas F, Al Olama, AA, Muir, Ken, Jenny L Donovan, Rahman, A A, Muir, K, Rosalind A Eeles, Hamdy, Freddie C., Olama Ali Amin Al, Aneela A. Rahman, Guy, Michelle, Kedda Mary-Anne, Srinivasan Srilakshmi, Donovan, Jenny L., Stephens, C, Aitken, Joanne, Yaxley, John, Clements, Judith A., Donovan, Jenny L, Hamdy, Freddie C, Al Olama, A A, Srinivasan, S, O'Mara, T, Hamdy, FC, Donovan, JL, Guy Michelle, Louise Marquart, Rahman, AA, Lose Felicity, Kedda, MA, Suzanne Chambers, David E. Neal, A. Rahman, Aneela, F. Easton, Douglas, Lophatananon Artitaya, Chambers Suzanne, Gardiner, R A, A. Clements, Judith, C. Hamdy, Freddie, Batra, J, Easton Douglas F., Neal David E., Clements Judith A., Spurdle, Amanda B., A. Eeles, Rosalind, Spurdle, AB, Neal, David E, Neal, David, Eeles, Rosalind A, Easton, DF, L. Donovan, Jenny, Douglas F. Easton, Stephens Carson, Spurdle, A. B., Easton, D F, A. Gardiner, Robert, Donovan, Jenny, Rosalind A. Eeles, Gardiner, Robert, Clements, J. A., Kote-Jarai, Zsofia, Eeles, Rosalind, Easton, Douglas, Gardiner Robert A., Aitken Joanne, Srilakshmi Srinivasan, Rahman, Aneela A., Neal, David E., Freddie C. Hamdy, Kote-Jarai, Z, Freddie C Hamdy, B. Spurdle, Amanda, Ali Amin Al Olama, Yaxley, J, Rahman Aneela A., Guy, M, Easton, Douglas F., O'Mara, Tracy, Alexander, Kimberly, Spurdle, Amanda B, Chambers, Suzanne, Felicity Lose, Gardiner, Robert A, Donovan, J L, Alexander, Kimberley, Clements, Judith A, Robert A. Gardiner, David E Neal, Judith A. Clements, Clements, JA, Muir Kenneth, Kedda, Mary-Anne, Clements, J A, Gardiner, RA, Clements, Judith, Marquart Louise, Batra, Jyotsna, Al Olama, Ali Amin, Lose, F, Eeles, R A, Srinivasan, Srilakshmi, Neal, D E, Marquart, L, Amanda B Spurdle, Mary-Anne Kedda, Donovan Jenny L., Muir, Kenneth, Aitken, J, Neal, DE, Batra Jyotsna, Lophatananon, Aritaya, Rahman, Aneela A, Robert A Gardiner, Spurdle, A B, Eeles, RA, John Yaxley, O'Mara Tracy, Douglas F Easton, Hamdy, F C, Stephens, Carson, Tracy O'Mara, Michelle Guy, Zsofia Kote-Jarai, Hamdy, Freddie, Spurdle, Amanda, Eeles Rosalind A., Yaxley John, Kote-Jarai Zsofia, Kimberly Alexander, Alexander Kimberly, Aneela A Rahman, Hamdy Freddie C., Spurdle Amanda B., Jenny L. Donovan, E. Neal, David, Amanda B. Spurdle, Lose, Felicity, Jyotsna Batra, Olama, Ali Amin Al, Chambers, S, Eeles, Rosalind A., Lophatananon, Artitaya   +152 more
core   +1 more source

Genome-Wide Expression Quantitative Trait Loci Analysis Using Mixed Models

Frontiers in Genetics, 2018
Expression quantitative trait loci (eQTLs) are important for understanding the genetic basis of cellular activities and complex phenotypes. Genome-wide eQTL analyses can be effectively conducted by employing a mixed model. The mixed model includes random
Chaeyoung Lee
doaj   +1 more source

Causal effect of polyunsaturated fatty acids on bone mineral density and fracture

Frontiers in Nutrition, 2022
BackgroundPolyunsaturated fatty acids (PUFAs) are closely related to osteoporosis. To test their causal relationship, we conducted a Mendelian randomization (MR) analysis.MethodsWe analyzed the causal relationship between four PUFAs measures, n-3 PUFAs ...
Sha-Sha Tao, Sha-Sha Tao, Sha-Sha Tao, Peng Wang, Xin-Yi Wang, Xin-Yi Wang, Kang-Jia Yin, Kang-Jia Yin, Xiao-Ke Yang, Zhi-Xin Wang, De-Guang Wang, Hai-Feng Pan, Hai-Feng Pan   +12 more
doaj   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Genetic association with subgingival bacterial colonization in chronic periodontitis [PDF]

, 2018
Chronic periodontitis is the most prevalent form of inflammatory destructive bone disease and has been affecting humans since antiquity. Evidence suggest that genetic factors can highly influence periodontitis risk, modulating disease elements such as ...
Melchiades, Jessica, Franco Cavalla, Cavalla Ruiz, Ian, Soriani Azevedo, Michelle, Claudia Biguetti, Pantenuci Tabanez, Andre, Garlet, Gustavo P., Andre Tabanez, Magda Feres, Faveri, Marcelo, Ana Favaro Trombone, Tabanez, Andre, Jessica Lima Melchiades, Cavalla, Franco, Biguetti, Cláudia Cristina, Biguetti, Claudia, Gustavo Pompermaier Garlet, Lima Melchiades, Jessica, Garlet, Gustavo, Favaro Trombone, Ana Paula, Marcelo Faveri, Favaro Trombone, Ana, Soriani Azevedo, Michelle de Campos, Feres, Magda, Michelle de Campos Soriani Azevedo   +24 more
core   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Contribution of Rare and Common APOE Variants to Familial Hypercholesterolemia in Spanish Cohort

Cardiogenetics
Our aim was to determine whether rare APOE pathogenic variants (PV) and the common e2/e3/e4 polymorphism were associated with the risk of familial hypercholesterolemia (FH).
Lorena M. Vega-Prado, Daniel Vázquez-Coto, Francisco Villazón, Lorena Suárez-Gutiérrez, Ceferino Martínez-Faedo, Edelmiro Menéndez-Torre, María Riestra, Silvia González-Martínez, Gala Gutiérrez-Buey, Claudia García-Lago, Juan Gómez, Victoria Alvarez, Helena Gil, Rebeca Lorca, Eliecer Coto   +14 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia

Behavioral and Brain Functions, 2012
Background The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors ...
Uezato Akihito, Kimura-Sato Junko, Yamamoto Naoki, Iijima Yoshimi, Kunugi Hiroshi, Nishikawa Toru   +5 more
doaj   +1 more source