Results 61 to 70 of about 2,782,325 (342)

Discovery of Sexual Dimorphisms in Metabolic and Genetic Biomarkers [PDF]

, 2007
Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.
Mittelstrass, Kirstin, Ried, Janina S., Yu, Zhonghao, Krumsiek, Jan, Gieger, Christian, Prehn, Cornelia, Roemisch-Margl, Werner, Polonikov, Alexey, Peters, Annette, Theis, Fabian J., Meitinger, Thomas, Kronenberg, Florian, Weidinger, Stephan, Wichmann, Heinz-Erich, Suhre, Karsten, Wang-Sattler, Rui, Adamski, Jerzy, Illig, Thomas   +17 more
core   +2 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. [PDF]

, 2014
To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and ...
Abecasis, Goncalo R, Adair, Linda S, Almgren, Peter, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, Atalay, Mustafa, Aung, Tin, Baldassarre, Damiano, Balkau, Beverley, Bao, Yuqian, Barnett, Anthony H, Barroso, Ines, Basit, Abdul, Been, Latonya F, Beilby, John, Bell, Graeme I, Below, Jennifer E, Benediktsson, Rafn, Bergman, Richard N, Boehm, Bernhard O, Boerwinkle, Eric, Bonnycastle, Lori L, Burtt, Noël, Cai, Qiuyin, Campbell, Harry, Carey, Jason, Cauchi, Stephane, Caulfield, Mark, Chan, Juliana CN, Chang, Li-Ching, Chang, Tien-Jyun, Chang, Yi-Cheng, Charpentier, Guillaume, Chen, Chien-Hsiun, Chen, Han, Chen, Yuan-Tsong, Chia, Kee-Seng, Chidambaram, Manickam, Chines, Peter S, Cho, Nam H, Cho, Young Min, Chuang, Lee-Ming, Chuang, Lee-Ming, Collins, Francis S, Cornelis, Marylin C, Couper, David J, Crenshaw, Andrew T, Danesh, John, Das, Debashish, de Faire, Ulf, Dedoussis, George, Deloukas, Panos, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Dimas, Antigone S, Dina, Christian, Doney, Alex S, Donnelly, Peter J, Dorkhan, Mozhgan, Dupuis, Josée, Edkins, Sarah, Elliott, Paul, Emilsson, Valur, Erbel, Raimund, Eriksson, Johan G, Escobedo, Jorge, Esko, Tonu, Eury, Elodie, Ferreira, Teresa, Florez, Jose C, Fontanillas, Pierre, Forouhi, Nita G, Forsen, Tom, Fox, Caroline, Fraser, Ross M, Frayling, Timothy M, Froguel, Philippe, Frossard, Philippe, Gao, Yutang, Gaulton, Kyle J, Gertow, Karl, Gieger, Christian, Gigante, Bruna, Go, Min Jin, Grallert, Harald, Grant, George B, Groves, Chrisropher J, Grrop, Leif C, Horikoshi, Momoko, Johnson, Andrew D, Mahajan, Anubha, Mexican American Type 2 Diabetes (MAT2D) Consortium, Ng, Maggie CY, Prokopenko, Inga, Saleheen, Danish, South Asian Type 2 Diabetes (SAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, van Dam, Rob M, van Duijn, Cornelia, Wang, Xu, Zeggini, Eleftheria, Zhang, Weihua   +99 more
core  

Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation. [PDF]

, 2019
Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders.
Andreassen, Ole A, Dale, Anders M, Djurovic, Srdjan, Fan, Chun Chieh, Frei, Oleksandr, Holland, Dominic, Maeland, Steffen, O'Connell, Kevin S, Shadrin, Alexey A, Smeland, Olav B, Thompson, Wesley K, Wang, Yunpeng   +11 more
core   +3 more sources

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Contribution of Rare and Common APOE Variants to Familial Hypercholesterolemia in Spanish Cohort

Cardiogenetics
Our aim was to determine whether rare APOE pathogenic variants (PV) and the common e2/e3/e4 polymorphism were associated with the risk of familial hypercholesterolemia (FH).
Lorena M. Vega-Prado, Daniel Vázquez-Coto, Francisco Villazón, Lorena Suárez-Gutiérrez, Ceferino Martínez-Faedo, Edelmiro Menéndez-Torre, María Riestra, Silvia González-Martínez, Gala Gutiérrez-Buey, Claudia García-Lago, Juan Gómez, Victoria Alvarez, Helena Gil, Rebeca Lorca, Eliecer Coto   +14 more
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia

Behavioral and Brain Functions, 2012
Background The synapse-associated protein 97 gene (SAP97) encodes a regulatory scaffold protein for the localization of L-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainate and N-methyl-D-aspartate (NMDA) type glutamate receptors ...
Uezato Akihito, Kimura-Sato Junko, Yamamoto Naoki, Iijima Yoshimi, Kunugi Hiroshi, Nishikawa Toru   +5 more
doaj   +1 more source

Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation [PDF]

, 2005
We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients.
Gunasekara Sudari Wijewickrama, Hettihewa Lukshmy Menik, Imendra Kotapola, Jayasinghe Sudheera Sammanthi, Palangasinghe Shalika, Weerarathna Thilak Priyantha   +5 more
core   +1 more source