Results 41 to 50 of about 226,034 (265)

Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Medicina, 2022
Checkpoint programmed death-1 (PD-1) has been identified as an immunosuppressive molecule implicated in the immune evasion of transformed cells. It is highly expressed in tumor cells in order to evade host immunosurveillance.
Nouf Al-Harbi, Mansoor-Ali Vaali-Mohammed, Suliman Al-Omar, Ahmed Zubaidi, Omar Al-Obeed, Maha-Hamadien Abdulla, Lamjed Mansour   +6 more
doaj   +1 more source

Genetics of Anthracycline-Associated Cardiotoxicity

Frontiers in Cardiovascular Medicine, 2022
Anthracyclines are a major component of chemotherapies used in many pediatric and adult malignancies. Anthracycline-associated cardiotoxicity (ACT) is a dose-dependent adverse effect that has substantial impact on morbidity and mortality. Therefore, the identification of genetic variants associated with increased risk of ACT has the potential for ...
Talal Khalid Al-Otaibi, Benjamin Weitzman, Usman A. Tahir, Aarti Asnani   +3 more
openaire   +3 more sources

Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction

, 2011
A. Burri, Q. Rahman and T. Spector (2011). Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction. Psychological Medicine, 41, pp 2435-2445. Copyright © Cambridge University Press 2011. http://dx.doi.
Burri, A, Rahman, Q, Rahman, Qazi; id_orcid, Spector, T, Spector, T., T. Spector, A. Burri, Q. Rahman, Burri, A.   +8 more
core   +1 more source

Association analysis of Epworth Sleepiness Scale (ESS) scores with serotonin transporter (5-HTT- LPR, 5-HTT-VNTR) and circadian (PER3-VNTR) genes [PDF]

Sleep Science
Excessive daytime sleepiness (EDS) is a common complaint encountered in clinical practice with serious consequences both for individual and society since it can increase the ratio of motor vehicle accidents, work- related incidents, and deaths. Moreover,
Filiz Ozen, Zeynep Yegin, Zuhal Aydan Saglam, Figen Yavlal, Haydar Koc, Celal Ulasoglu   +5 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Exploring genetic associations of Crohn’s disease and ulcerative colitis with extraintestinal cancers in European and East Asian populations

Frontiers in Immunology
BackgroundPrevious studies have reported associations of Crohn’s disease (CD) and ulcerative colitis (UC) with the risks of extraintestinal cancers, but the causality remains unclear.MethodsUsing genetic variations robustly associated with CD and UC ...
Chengdong Yu, Jiawei Xu, Siyi Xu, Lei Tang, Qinyuan Han, Xiaoqiang Zeng, Yanxiao Huang, Tenghua Yu, Zhengkui Sun   +8 more
doaj   +1 more source

Association of genetic variants with dyslipidemia

Molecular Medicine Reports, 2015
Although genetic variants, which regulate lipid metabolism, have been extensively investigated in Caucasian populations, the genes, which confer susceptibility to dyslipidemia in Japanese individuals, remain to be elucidated. The aim of the present study was to examine a possible association among hypertriglyceridemia, hypo‑high density lipoprotein ...
Shintaro, Abe, Fumitaka, Tokoro, Reiko, Matsuoka, Masazumi, Arai, Toshiyuki, Noda, Sachiro, Watanabe, Hideki, Horibe, Tetsuo, Fujimaki, Mitsutoshi, Oguri, Kimihiko, Kato, Shinya, Minatoguchi, Yoshiji, Yamada   +11 more
openaire   +3 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

The anatomical distribution of genetic associations [PDF]

Nucleic Acids Research, 2015
Abstract Deeper understanding of the anatomical intermediaries for disease and other complex genetic traits is essential to understanding mechanisms and developing new interventions. Existing ontology tools provide functional annotations for many genes in the genome and they are widely used to develop mechanistic hypotheses based on ...
Wells, Alan, Kopp, Nathan, Xu, Xiaoxiao, O'Brien, David R, Yang, Wei, Nehorai, Arye, Adair-Kirk, Tracy L, Kopan, Raphael, Dougherty, J D   +8 more
openaire   +3 more sources