Results 51 to 60 of about 11,195,425 (262)

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Association between Prostinogen (KLK15) genetic variants and prostate cancer risk and aggressiveness in Australia and a meta-analysis of GWAS data [PDF]

, 2011
Background Kallikrein 15 (KLK15)/Prostinogen is a plausible candidate for prostate cancer susceptibility. Elevated KLK15 expression has been reported in prostate cancer and it has been described as an unfavorable prognostic marker for the disease ...
Artitaya Lophatananon, Judith A Clements, Lophatananon, A, Rahman, Aneela, Marquart, Louise, Joanne Aitken, Kenneth Muir, Kedda, M A, Alexander, K, Gardiner, Robert A., Carson Stephens, Easton, Douglas F, Al Olama, AA, Muir, Ken, Jenny L Donovan, Rahman, A A, Muir, K, Rosalind A Eeles, Hamdy, Freddie C., Olama Ali Amin Al, Aneela A. Rahman, Guy, Michelle, Kedda Mary-Anne, Srinivasan Srilakshmi, Donovan, Jenny L., Stephens, C, Aitken, Joanne, Yaxley, John, Clements, Judith A., Donovan, Jenny L, Hamdy, Freddie C, Al Olama, A A, Srinivasan, S, O'Mara, T, Hamdy, FC, Donovan, JL, Guy Michelle, Louise Marquart, Rahman, AA, Lose Felicity, Kedda, MA, Suzanne Chambers, David E. Neal, A. Rahman, Aneela, F. Easton, Douglas, Lophatananon Artitaya, Chambers Suzanne, Gardiner, R A, A. Clements, Judith, C. Hamdy, Freddie, Batra, J, Easton Douglas F., Neal David E., Clements Judith A., Spurdle, Amanda B., A. Eeles, Rosalind, Spurdle, AB, Neal, David E, Neal, David, Eeles, Rosalind A, Easton, DF, L. Donovan, Jenny, Douglas F. Easton, Stephens Carson, Spurdle, A. B., Easton, D F, A. Gardiner, Robert, Donovan, Jenny, Rosalind A. Eeles, Gardiner, Robert, Clements, J. A., Kote-Jarai, Zsofia, Eeles, Rosalind, Easton, Douglas, Gardiner Robert A., Aitken Joanne, Srilakshmi Srinivasan, Rahman, Aneela A., Neal, David E., Freddie C. Hamdy, Kote-Jarai, Z, Freddie C Hamdy, B. Spurdle, Amanda, Ali Amin Al Olama, Yaxley, J, Rahman Aneela A., Guy, M, Easton, Douglas F., O'Mara, Tracy, Alexander, Kimberly, Spurdle, Amanda B, Chambers, Suzanne, Felicity Lose, Gardiner, Robert A, Donovan, J L, Alexander, Kimberley, Clements, Judith A, Robert A. Gardiner, David E Neal, Judith A. Clements, Clements, JA, Muir Kenneth, Kedda, Mary-Anne, Clements, J A, Gardiner, RA, Clements, Judith, Marquart Louise, Batra, Jyotsna, Al Olama, Ali Amin, Lose, F, Eeles, R A, Srinivasan, Srilakshmi, Neal, D E, Marquart, L, Amanda B Spurdle, Mary-Anne Kedda, Donovan Jenny L., Muir, Kenneth, Aitken, J, Neal, DE, Batra Jyotsna, Lophatananon, Aritaya, Rahman, Aneela A, Robert A Gardiner, Spurdle, A B, Eeles, RA, John Yaxley, O'Mara Tracy, Douglas F Easton, Hamdy, F C, Stephens, Carson, Tracy O'Mara, Michelle Guy, Zsofia Kote-Jarai, Hamdy, Freddie, Spurdle, Amanda, Eeles Rosalind A., Yaxley John, Kote-Jarai Zsofia, Kimberly Alexander, Alexander Kimberly, Aneela A Rahman, Hamdy Freddie C., Spurdle Amanda B., Jenny L. Donovan, E. Neal, David, Amanda B. Spurdle, Lose, Felicity, Jyotsna Batra, Olama, Ali Amin Al, Chambers, S, Eeles, Rosalind A., Lophatananon, Artitaya   +152 more
core   +2 more sources

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Genetic analysis of protein composition of bovine milk [PDF]

, 2010
This thesis is part of the Dutch Milk Genomics Initiative, and the general aim was to obtain more insight into the genetic background of bovine milk protein composition.
Schopen, G.C.B.
core  

Genome-Wide Expression Quantitative Trait Loci Analysis Using Mixed Models

Frontiers in Genetics, 2018
Expression quantitative trait loci (eQTLs) are important for understanding the genetic basis of cellular activities and complex phenotypes. Genome-wide eQTL analyses can be effectively conducted by employing a mixed model. The mixed model includes random
Chaeyoung Lee
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Contribution of Rare and Common APOE Variants to Familial Hypercholesterolemia in Spanish Cohort

Cardiogenetics
Our aim was to determine whether rare APOE pathogenic variants (PV) and the common e2/e3/e4 polymorphism were associated with the risk of familial hypercholesterolemia (FH).
Lorena M. Vega-Prado, Daniel Vázquez-Coto, Francisco Villazón, Lorena Suárez-Gutiérrez, Ceferino Martínez-Faedo, Edelmiro Menéndez-Torre, María Riestra, Silvia González-Martínez, Gala Gutiérrez-Buey, Claudia García-Lago, Juan Gómez, Victoria Alvarez, Helena Gil, Rebeca Lorca, Eliecer Coto   +14 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source