Results 31 to 40 of about 226,034 (265)

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]

open access: yes, 2014
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...
Rasmussen-Torvik, Laura J.   +585 more
core   +1 more source

Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

open access: yesFrontiers in Psychiatry, 2019
Aims: Serotonin 1A receptor (5-HT1A) and vascular endothelial growth factor (VEGF) are widely expressed in the neurons of the hippocampus and have significant roles in the pathophysiological processes of major depressive disorders (MDDs).
Dong Han   +11 more
doaj   +1 more source

Systematic Review of Genomic Associations with Blood Pressure and Hypertension in Populations with African-Ancestry

open access: yesFrontiers in Genetics, 2021
Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh   +6 more
doaj   +1 more source

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy [PDF]

open access: yes, 2011
The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc).
Kreuter, A   +607 more
core   +1 more source

Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk

open access: yesRadiology and Oncology, 2016
Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in ...
Hudler Petra   +3 more
doaj   +1 more source

Genetic disorders associated with macrocephaly [PDF]

open access: yesAmerican Journal of Medical Genetics Part A, 2008
AbstractMacrocephaly is associated with many genetic disorders and is a frequent cause of referral to the clinical geneticist. In this review we classify the commonly encountered macrocephaly disorders into useful categories and summarize recent genetic advances.
Williams, Charles A.   +2 more
openaire   +3 more sources

A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample [PDF]

open access: yes, 2011
Rationale: Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits,
Shrine, Nick   +406 more
core   +1 more source

Association of African genetic admixture with resting metabolic rate and obesity among women.

open access: yes, 2003
OBJECTIVE: To investigate the role of genetic admixture in explaining phenotypic variation in obesity-related traits in a sample of African-American women (n = 145) and to determine significant associations between obesity traits and admixture genetic ...
Shriver, Mark D   +11 more
core   +1 more source

Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children

open access: yesHuman Genomics, 2011
Type 2 diabetes represents an increasing health burden. Its prevalence is rising among younger age groups and differs among racial/ethnic groups. Little is known about its genetic basis, including whether there is a genetic basis for racial/ethnic ...
Klimentidis Yann C   +5 more
doaj   +1 more source

Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia

open access: yesBiomolecules & Biomedicine, 2012
Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder.
Lilijana Oruč   +4 more
doaj   +1 more source

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