Results 21 to 30 of about 11,195,425 (262)

ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population

open access: yesFrontiers in Neuroscience, 2021
Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan   +11 more
doaj   +1 more source

Association of genetic variants at 8q24 with breast cancer risk. [PDF]

open access: yes, 2008
Recent whole genome association studies of prostate, breast, and colorectal cancer have identified susceptibility loci on 8q24. We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both ...
Johnson, Nichola   +9 more
core   +1 more source

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity [PDF]

open access: yes, 2010
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes.
Kaprio J   +305 more
core   +1 more source

Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations

open access: yesGenetics and Molecular Biology, 2017
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors.
Lixia Yu   +9 more
doaj   +1 more source

A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample [PDF]

open access: yes, 2011
Rationale: Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits,
Shrine, Nick   +406 more
core   +1 more source

Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

open access: yesFrontiers in Psychiatry, 2019
Aims: Serotonin 1A receptor (5-HT1A) and vascular endothelial growth factor (VEGF) are widely expressed in the neurons of the hippocampus and have significant roles in the pathophysiological processes of major depressive disorders (MDDs).
Dong Han   +11 more
doaj   +1 more source

Systematic Review of Genomic Associations with Blood Pressure and Hypertension in Populations with African-Ancestry

open access: yesFrontiers in Genetics, 2021
Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh   +6 more
doaj   +1 more source

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes [PDF]

open access: yes, 2014
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies ...
Rasmussen-Torvik, Laura J.   +585 more
core   +2 more sources

Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk

open access: yesRadiology and Oncology, 2016
Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in ...
Hudler Petra   +3 more
doaj   +1 more source

Association of African genetic admixture with resting metabolic rate and obesity among women.

open access: yes, 2003
OBJECTIVE: To investigate the role of genetic admixture in explaining phenotypic variation in obesity-related traits in a sample of African-American women (n = 145) and to determine significant associations between obesity traits and admixture genetic ...
Shriver, Mark D   +11 more
core   +1 more source

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