Results 21 to 30 of about 226,034 (265)

Systematic Review of Genetic Factors in the Etiology of Esophageal Squamous Cell Carcinoma in African Populations

Frontiers in Genetics, 2019
Background: Esophageal squamous cell carcinoma (ESCC), one of the most aggressive cancers, is endemic in Sub-Saharan Africa, constituting a major health burden.
Hannah Simba, Helena Kuivaniemi, Vittoria Lutje, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Gerard Tromp, Vikash Sewram   +8 more
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Variable Effects of PD-Risk Associated SNPs and Variants in Parkinsonism-Associated Genes on Disease Phenotype in a Community-Based Cohort

Frontiers in Neurology, 2021
Genetic risk factors for Parkinson's disease (PD) risk and progression have been identified from genome-wide association studies (GWAS), as well as studies of familial forms of PD, implicating common variants at more than 90 loci and pathogenic or likely
Katerina Markopoulou, Bruce A. Chase, Ashvini P. Premkumar, Bernadette Schoneburg, Ninith Kartha, Jun Wei, Hongjie Yu, Alexander Epshteyn, Lisette Garduno, Anna Pham, Rosa Vazquez, Roberta Frigerio, Demetrius Maraganore   +12 more
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A survey of genetic improvement search spaces [PDF]

, 2019
Genetic Improvement (GI) uses automated search to improve existing software. Most GI work has focused on empirical studies that successfully apply GI to improve software's running time, fix bugs, add new features, etc. There has been little research into
Alexander, B, Petke, Justyna, Alexander, Brad, Petke, J, White, DR, Wagner, M., Barr, ET, White, David R, Wagner, M, Barr, Earl T, Alexander, B., White, D.R., Petke, J., Barr, E.T., Brownlee, AEI, Brownlee, Alexander E I, Wagner, Markus, Brownlee, A.E.I.   +17 more
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Analysis of the association between rs12917707 and rs11864909 single nucleotide polymorphisms in the region of the uromoduline gene and chronic kidney disease – a family-based study

Annals of Agricultural and Environmental Medicine, 2017
Chronic kidney disease (CKD) is an important challange for healthcare systems wordwide because of its high prevalence and serious late complications.
Joanna Żywiec, Katarzyna Kiliś-Pstrusińska, Maciej Tomaszewski, Władysław Grzeszczak   +3 more
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Validation in Genetic Association Studies [PDF]

Briefings in Bioinformatics, 2011
Validation of genetic associations is understood to be a cornerstone for the scientific credibility of the results. To approach this topic, the general concept of genetic association studies is introduced briefly, followed by how the term 'validation' is used in the context of genetic association studies.
openaire   +2 more sources

Association of genetic variants at 8q24 with breast cancer risk. [PDF]

, 2008
Recent whole genome association studies of prostate, breast, and colorectal cancer have identified susceptibility loci on 8q24. We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both ...
Johnson, Nichola, Fletcher, Olivia, Coupland, Ben, dos Santos Silva, Isabel, Gibson, Lorna, Leonard, Angela, Fraser, Agnes, Ashworth, Alan, Houlston, Richard, Peto, Julian   +9 more
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ALDH1A1 Genetic Variations May Modulate Risk of Parkinson’s Disease in Han Chinese Population

Frontiers in Neuroscience, 2021
Background: Studies in animal models have suggested that aldehyde dehydrogenase 1 (encoded by ALDH1A1) protects against Parkinson’s disease (PD) by reducing toxic metabolites of dopamine.
Hui-Hui Fan, Hui-Hui Fan, Qing Guo, Jing Zheng, Yi-Zhi Lian, Shi-Shi Huang, Yue Sun, Ming Zou, Jian-Hong Zhu, Jian-Hong Zhu, Xiong Zhang, Xiong Zhang   +11 more
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Introduction to Genetic Association Studies [PDF]

Cold Spring Harbor Protocols, 2012
Genetic association studies are used to find candidate genes or genome regions that contribute to a specific disease by testing for a correlation between disease status and genetic variation. This article provides a broad outline of the design and analysis of such studies, focusing on case–control studies in candidate genes or regions.
Lewis, Cathryn M, Knight, Jo
openaire   +3 more sources

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity [PDF]

, 2010
Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes.
Kaprio J, Pillai S, Martin NG, Saccone NL, Leppert Mark F., Marissa A Ehringer, Wang, Jen C., Witt, Stephanie H., Jensen, Majken K., Sarah H. Stephens, Younghun Han, Peter Kraft, Amos Christopher I., Robert B Weiss, Culverhouse, Robert C., Broderick Peter, Stephanie H Witt, Bierut Laura J., Maria Teresa L, Culverhouse Robert C., Breslau Naomi, Markus M. Nöthen, Gapstur Susan M., Niu, Tianhua, Jen C Wang, Han, Younghun, Witt Stephanie H., Heliovaara, Markku, Thomas J Payne, Andrew C. Heath, Han, Shizhong, Landi MT, Kaprio, Jaakko, Yang BZ, Martin, Nicholas G., Gapstur, Susan M., Kendler KS, Wheeler William, Yufei Wang, Witt SH, Kendler Kenneth S., Wheeler, William, John P. Rice, Kaisu Keskitalo-Vuokko, Hunter David J., Margaret R Spitz, Sarah H Stephens, Ann Schwartz, Spitz, Margaret R., Nancy L. Saccone, Stephens SH, Ming D. Li, Wang JC, Dale S Cannon, Leena Peltonen, David J Hunter, Angela S. Wenzlaff, Andrew C Heath, Caporaso Neil E., Weiss Robert B., Hoft, Nicole R., Payne Thomas J., Neil E. Caporaso, Keskitalo-Vuokko, Kaisu, Landi, Maria Teresa, Breslau N, Sven Cichon, Xiangyang Kong, Breslau, Naomi, Hoft NR, Rietschel Marcella, Stevens VL, Noethen, Markus M., Nöthen, Markus M., Michele L Pergadia, Heliövaara M, Laura J Bierut, Chatterjee N, Michele L. Pergadia, Susan E Short, Robert C Culverhouse, Ina Giegling, Sun Lingwei, Chen X, Kaprio Jaakko, Jensen MK, Stephens Sarah H., Sherva R, Laura J. Bierut, Chen J, Li MD, Heath AC, Nicole R. Hoft, Majken K Jensen, Broderick P, Stevens Victoria L., Martin Nicholas G., Sherva, Richard, Marcella Rietschel, Aggen SH, Nancy L Saccone, Stephens, Sarah H., Peltonen, Leena, Sreekumar Pillai, Cannon Dale S., Sun, Lingwei, Eisen Tim, Mark F. Leppert, Angela S Wenzlaff, Giegling Ina, Bierut LJ, Heliovaara, Marku, Maria Teresa Landi, Pergadia Michele L., Markku Heliövaara, Hunter DJ, Stevens, Victoria L., Kenneth S Kendler, Keskitalo-Vuokko Kaisu, Cannon, Dale S., Ehringer, Marissa A., Schwantes-An Tae-Hwi, Landi, Maria T., Thomas J. Payne, Li Ming D., Peter Broderick, Montgomery GW, Cichon, Sven, Jingchun Chen, John P Rice, Han Younghun, Wang Jen C., Chen Jingchun, Aggen Steven H., Rujescu D, Nicholas G Martin, Rice John P., Pergadia, Michele L., Jennie Z Ma, Yang Bao-Zhu, Eisen T, Marissa A, Nilanjan Chatterjee, Hunter, David J., Madden Pamela A. F., Victoria L. Stevens, Neil E Caporaso, Sun, Juzhong, Steven H Aggen, Nicholas G. Martin, Kenneth S. Kendler, Chen, Xiangning, Cichon S, Landi Maria Teresa, Joel Gelernter, Mark F Leppert, William Wheeler, Gelemter, Joel, Heliövaara Markku, Kraft Peter, Susan E. Short, Saccone Nancy L., Gelernter Joel, Susan M. Gapstur, Chen, Jingchun, Cichon Sven, Wenzlaff AS, Tim Eisen, Heath Andrew C., Madden PA, Pillai, Sreekumar, Robert C. Culverhouse, Lingwei Sun, Chen Xiangning, Rice, John P., Bao-Zhu Yang, Chatterjee, Nilanjan, Richard Houlston, Kraft, Peter, Majken K. Jensen, Rice JP, Shizhong Han, Nicole R Hoft, Pergadia ML, Saccone, Nancy L., Ming D Li, Han Y, Sherva Richard, Montgomery Grant W., Han S, Culverhouse RC, Victoria L Stevens, Kong Xiangyang, Wheeler W, Pamela A F Madden, Dan Rujescu, Ma JZ, Gapstur SM, Steven H. Aggen, Christopher I. Amos, Wenzlaff Angela S., Schwartz Ann, Caporaso NE, Cannon DS, Hoft Nicole R., Short, Susan E., Tianhua Niu, Jen C. Wang, Eisen, Tim, Leppert MF, Wang Yufei, Niu Tianhua, Caporaso, Neil E., Heath, Andrew C., Kong, Xiangyang, Broderick, Peter, Schwartz, Ann, Juzhong Sun, Wenzlaff, Angela S., Weiss, Robert B., Bierut, Laura J., Peltonen L, Rujescu, Dan, Kong X, Yang, Bao-Zhu, Wang, Yufei, Christopher I Amos, Houlston R, Rujescu Dan, Weiss RB, Susan M Gapstur, Houlston Richard, Rietschel M, Schwantes-An, Tae-Hwi, Leppert, Mark F., Giegling, Ina, Richard Sherva, Montgomery, Grant W., Sun L, Amos CI, Gelernter J, Li, Ming D., Schwantes-An TH, Ehringer MA, Ma, Jennie Z., Sun Juzhong, Wang Y, Sun J, Kendler, Kenneth S., Xiangning Chen, Palotie, Leena, Payne TJ, Tae-Hwi Schwantes-An, Jaakko Kaprio, Nöthen Markus M., Naomi Breslau, Marissa A. Ehringer, Aggen, Steven H., Payne, Thomas J., Robert B, Kraft P, Grant W Montgomery, Margaret R. Spitz, Chatterjee Nilanjan, Spitz Margaret R., Houlston, Richard, Keskitalo-Vuokko K, Ma Jennie Z., David J. Hunter, Niu T, Stephanie H. Witt, Short Susan E., Rietschel, Marcella, Nöthen MM, Schwartz A, Grant W, Pillai Sreekumar, Markus M Nöthen, Pamela A. F. Madden, Han Shizhong, Amos, Christopher I., Giegling I, Dale S. Cannon, Grant W. Montgomery, Jensen Majken K., Spitz MR, Peltonen Leena, Gelernter, Joel, Jennie Z. Ma, Pamela A. F, Short SE, Robert B. Weiss, Madden, Pamela A. F., Ehringer Marissa A.   +293 more
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Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations

Genetics and Molecular Biology, 2017
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors.
Lixia Yu, Xiaoai Zhang, Yun Zhai, Hongxing Zhang, Wei Yue, Xiumei Zhang, Zhifu Wang, Hong Zhou, Gangqiao Zhou, Feng Gong   +9 more
doaj   +1 more source