Results 21 to 30 of about 1,391,897 (268)

Introduction to Genetic Association Studies [PDF]

Cold Spring Harbor Protocols, 2012
Genetic association studies are used to find candidate genes or genome regions that contribute to a specific disease by testing for a correlation between disease status and genetic variation. This article provides a broad outline of the design and analysis of such studies, focusing on case–control studies in candidate genes or regions.
Lewis, Cathryn M, Knight, Jo
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Association of polymorphisms in the heparanase gene (HPSE) with hepatocellular carcinoma in Chinese populations

Genetics and Molecular Biology, 2017
Heparanase activity is involved in cancer growth and development in humans and single nucleotide polymorphisms (SNPs) in the heparanase gene (HPSE) have been shown to be associated with tumors.
Lixia Yu, Xiaoai Zhang, Yun Zhai, Hongxing Zhang, Wei Yue, Xiumei Zhang, Zhifu Wang, Hong Zhou, Gangqiao Zhou, Feng Gong   +9 more
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Epistatic Interaction Between 5-HT1A and Vascular Endothelial Growth Factor Gene Polymorphisms in the Northern Chinese Han Population With Major Depressive Disorder

Frontiers in Psychiatry, 2019
Aims: Serotonin 1A receptor (5-HT1A) and vascular endothelial growth factor (VEGF) are widely expressed in the neurons of the hippocampus and have significant roles in the pathophysiological processes of major depressive disorders (MDDs).
Dong Han, Zhengxue Qiao, Dong Qi, Jiarun Yang, Xiuxian Yang, Jingsong Ma, Lin Wang, Xuejia Song, Erying Zhao, Jian Zhang, Yanjie Yang, Xiaohui Qiu   +11 more
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Systematic Review of Genomic Associations with Blood Pressure and Hypertension in Populations with African-Ancestry

Frontiers in Genetics, 2021
Background: Despite hypertension being highly prevalent in individuals with African-ancestry, they are under-represented in large genome-wide association studies.
S. Singh, S. Singh, J-T. Brandenburg, A. Choudhury, F.X. Gómez-Olivé, M. Ramsay, M. Ramsay   +6 more
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Association between polymorphisms in segregation genes BUB1B and TTK and gastric cancer risk

Radiology and Oncology, 2016
Malignant transformation of normal gastric cells is a complex and multistep process, resulting in development of heterogeneous tumours. Susceptible genetic background, accumulation of genetic changes, and environmental factors play an important role in ...
Hudler Petra, Britovsek Nina Kocevar, Grazio Snjezana Frkovic, Komel Radovan   +3 more
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Genetic disorders associated with macrocephaly [PDF]

American Journal of Medical Genetics Part A, 2008
AbstractMacrocephaly is associated with many genetic disorders and is a frequent cause of referral to the clinical geneticist. In this review we classify the commonly encountered macrocephaly disorders into useful categories and summarize recent genetic advances.
Williams, Charles A., Dagli, Aditi, Battaglia, Agatino   +2 more
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Ancestry-informative markers on chromosomes 2, 8 and 15 are associated with insulin-related traits in a racially diverse sample of children

Human Genomics, 2011
Type 2 diabetes represents an increasing health burden. Its prevalence is rising among younger age groups and differs among racial/ethnic groups. Little is known about its genetic basis, including whether there is a genetic basis for racial/ethnic ...
Klimentidis Yann C, Divers Jasmin, Casazza Krista, Beasley T, Allison David B, Fernandez Jose R   +5 more
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Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia

Biomolecules & Biomedicine, 2012
Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder.
Lilijana Oruč, Lejla Kapur-Pojskić, Jasmin Ramić, Naris Pojskić, Kasim Bajrović   +4 more
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Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer

Medicina, 2022
Checkpoint programmed death-1 (PD-1) has been identified as an immunosuppressive molecule implicated in the immune evasion of transformed cells. It is highly expressed in tumor cells in order to evade host immunosurveillance.
Nouf Al-Harbi, Mansoor-Ali Vaali-Mohammed, Suliman Al-Omar, Ahmed Zubaidi, Omar Al-Obeed, Maha-Hamadien Abdulla, Lamjed Mansour   +6 more
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Genetics of Anthracycline-Associated Cardiotoxicity

Frontiers in Cardiovascular Medicine, 2022
Anthracyclines are a major component of chemotherapies used in many pediatric and adult malignancies. Anthracycline-associated cardiotoxicity (ACT) is a dose-dependent adverse effect that has substantial impact on morbidity and mortality. Therefore, the identification of genetic variants associated with increased risk of ACT has the potential for ...
Talal Khalid Al-Otaibi, Benjamin Weitzman, Usman A. Tahir, Aarti Asnani   +3 more
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